Pygo2 - pygopus 2 Gene

Also Known as 1190004M21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 68911

Summary

Enables chromatin binding activity; Histone Acetyltransferase regulator activity; and histone binding activity. Involved in canonical Wnt signaling pathway. Acts upstream of or within several processes, including animal organ development; positive regulation of chromatin binding activity; and spermatid nucleus differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and skin. Orthologous to human PYGO2 (pygopus family PHD finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Pygo2 Products (5)

mRNA Protein Name
NM_001293763.1 NP_001280692.1 pygopus homolog 2 isoform b
NM_001293766.2 NP_001280695.1 pygopus homolog 2 isoform b
NM_001293767.1 NP_001280696.1 pygopus homolog 2 isoform b
NM_001293768.1 NP_001280697.1 pygopus homolog 2 isoform a
NM_026869.3 NP_081145.1 pygopus homolog 2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
23637336 MGI
enables histone acetyltransferase regulator activity IMP
IMP: Inferred from mutant phenotype
23637336 MGI
enables histone binding IDA
IDA: Inferred from direct assay
19487454 MGI
enables histone binding IMP
IMP: Inferred from mutant phenotype
23637336 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19487454 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anatomical structure development IGI
IGI: Inferred from genetic interaction
17425782 MGI
acts upstream of or within anatomical structure development IMP
IMP: Inferred from mutant phenotype
17425782 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
17425782 MGI
involved in canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
17425782 MGI
acts upstream of or within canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
17425782 MGI
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19487454 MGI
acts upstream of or within developmental growth IMP
IMP: Inferred from mutant phenotype
17425782 MGI
acts upstream of or within kidney development IGI
IGI: Inferred from genetic interaction
17425782 MGI
acts upstream of or within lens development in camera-type eye IMP
IMP: Inferred from mutant phenotype
17425782 MGI
acts upstream of or within mammary gland development IMP
IMP: Inferred from mutant phenotype
19487454 MGI
acts upstream of or within positive regulation of chromatin binding IMP
IMP: Inferred from mutant phenotype
23637336 MGI
acts upstream of or within regulation of mammary gland epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
19487454 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
17425782 MGI
acts upstream of or within spermatid development IGI
IGI: Inferred from genetic interaction
23637336 MGI
acts upstream of or within spermatid nucleus differentiation IGI
IGI: Inferred from genetic interaction
23637336 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
17425782 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pygopus homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-157891 JBC117 Inducer 99.71% Unkown
HY-RS11492 PYGO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pygo2 NCBI NCBI:90780