Fcmr - Fc fragment of IgM receptor Gene

Also Known as Toso; Faim3; FcmuR; 1810037B05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69169

Summary

Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within inhibition of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; and negative regulation of lymphocyte apoptotic process. Located in external side of plasma membrane. Orthologous to human FCMR (Fc fragment of IgM receptor). [provided by Alliance of Genome Resources, Apr 2022]

Fcmr Products (2)

mRNA Protein Name
NM_001405893.1 NP_001392822.1 fas apoptotic inhibitory molecule 3 isoform 2 precursor
NM_026976.4 NP_081252.1 fas apoptotic inhibitory molecule 3 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables IgM binding IDA
IDA: Inferred from direct assay
28135254 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15632112 MGI
Biological Process GO Annotation Evidence References Source
involved in humoral immune response mediated by circulating immunoglobulin IMP
IMP: Inferred from mutant phenotype
22988094 MGI
involved in immunoglobulin transcytosis in epithelial cells IDA
IDA: Inferred from direct assay
34788614 MGI
acts upstream of or within inhibition of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
15632112 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
15632112 MGI
acts upstream of or within negative regulation of lymphocyte apoptotic process IDA
IDA: Inferred from direct assay
15632112 MGI
involved in regulation of B cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
28135254 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
15632112 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
15632112 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
28135254 MGI
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
28135254 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fas apoptotic inhibitory molecule 3

  • IgM Fc fragment receptor

  • regulator of Fas-induced apoptosis Toso

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04838 FCMR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18931 Fcmr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25421 Fcmr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fcmr NCBI NCBI:9214