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Dab2ip - disabled 2 interacting protein Gene

Also Known as Aip1; mKIAA1743; 2310011D08Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 69601

Summary

Enables protein kinase binding activity. Involved in several processes, including cellular response to cytokine stimulus; neurogenesis; and regulation of signal transduction. Located in axon; cytoplasm; and neuronal cell body membrane. Part of AIP1-IRE1 complex. Is expressed in cartilage; telencephalon; and trigeminal ganglion. Orthologous to human DAB2IP (DAB2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]

Dab2ip Products (7)

mRNA	Protein	Name
NM_001001602.2	NP_001001602.2	disabled homolog 2-interacting protein isoform 3
NM_001114124.2	NP_001107596.1	disabled homolog 2-interacting protein isoform 2
NM_001114125.1	NP_001107597.1	disabled homolog 2-interacting protein isoform 1
NM_001290637.1	NP_001277566.1	disabled homolog 2-interacting protein isoform 4
NM_001290639.1	NP_001277568.1	disabled homolog 2-interacting protein isoform 6
NM_001290640.1	NP_001277569.1	disabled homolog 2-interacting protein isoform 5
NM_001290641.1	NP_001277570.1	disabled homolog 2-interacting protein isoform 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables Toll-like receptor 4 binding	IMP IMP: Inferred from mutant phenotype	19948740	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12877983	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	18281285	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cell motility involved in cerebral cortex radial glia guided migration	IMP IMP: Inferred from mutant phenotype	23056358	MGI
involved in cellular response to interleukin-1	IDA IDA: Inferred from direct assay	19948740	MGI
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	19948740	MGI
involved in cellular response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	18281285	MGI
involved in cellular response to vascular endothelial growth factor stimulus	IDA IDA: Inferred from direct assay	19033661	MGI
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	18281285	MGI
involved in layer formation in cerebral cortex	IMP IMP: Inferred from mutant phenotype	23056358	MGI
involved in negative regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	19948740	MGI
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	19033661	MGI
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20080667	MGI
involved in negative regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	19033661	MGI
involved in negative regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	20154697	MGI
involved in negative regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	19903888	MGI
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19033661	MGI
involved in negative regulation of vascular endothelial growth factor signaling pathway	IDA IDA: Inferred from direct assay	19033661	MGI
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	23056358	MGI
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	18281285	MGI
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	19903888	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	19948740	MGI
involved in positive regulation of dendrite development	IMP IMP: Inferred from mutant phenotype	23326475	MGI
involved in positive regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	23056358	MGI
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	23056358	MGI
involved in positive regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	19948740	MGI
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	19903888	MGI
involved in positive regulation of synapse maturation	IMP IMP: Inferred from mutant phenotype	23326475	MGI
involved in regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	19948740	MGI
involved in regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	19948740	MGI
involved in regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	19948740	MGI
involved in regulation of protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	19948740	MGI
involved in tube formation	IMP IMP: Inferred from mutant phenotype	19033661	MGI
involved in vascular endothelial growth factor receptor-2 signaling pathway	IMP IMP: Inferred from mutant phenotype	19033661	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of AIP1-IRE1 complex	IPI IPI: Inferred from physical interaction	18281285	MGI
located in axon	IDA IDA: Inferred from direct assay	23326475	MGI
located in cerebellar mossy fiber	IDA IDA: Inferred from direct assay	23326475	MGI
located in climbing fiber	IDA IDA: Inferred from direct assay	23326475	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	19948740	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	23326475	MGI
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	23056358	MGI
located in parallel fiber	IDA IDA: Inferred from direct assay	23326475	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	19948740	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
disabled homolog 2-interacting protein	ASK-interacting protein 1 ASK1-interacting protein 1 DAB2-interacting protein DOC-2/DAB-2 interactive protein disabled 2 interacting protein long form

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03512	DAB2IP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dab2ip	NCBI	NCBI:153090