DAB2IP - DAB2 interacting protein Gene

Also Known as AIP1; AIP-1; AF9Q34; DIP1/2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 153090

About DAB2IP

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:121,567,074-121,785,530 (from NCBI)

This gene has 11 transcripts (splice variants), 238 orthologues and 10 paralogues. Ubiquitous expression in colon (RPKM 8.5), testis (RPKM 8.5) and 24 other tissues.

Summary

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]

DAB2IP Products (3)

mRNA	Protein	Name
NM_001395010.1	NP_001381939.1	disabled homolog 2-interacting protein isoform 3
NM_032552.4	NP_115941.2	disabled homolog 2-interacting protein isoform 1
NM_138709.2	NP_619723.1	disabled homolog 2-interacting protein isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 14-3-3 protein binding	IDA IDA: Inferred from direct assay	17389591	GOA
enables SH3 domain binding	IDA IDA: Inferred from direct assay	19033661	GOA
NOT enables Toll-like receptor 4 binding	IDA IDA: Inferred from direct assay	19948740	GOA
enables death receptor binding	IPI IPI: Inferred from physical interaction	15310755	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	12813029	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	17389591	GOA
enables mitogen-activated protein kinase kinase binding	IPI IPI: Inferred from physical interaction	17389591	GOA
enables mitogen-activated protein kinase kinase kinase binding	IPI IPI: Inferred from physical interaction	12813029	GOA
enables phosphatidylinositol 3-kinase binding	IDA IDA: Inferred from direct assay	19033661	GOA
enables phosphatidylinositol 3-kinase regulatory subunit binding	IDA IDA: Inferred from direct assay	19903888	GOA
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	19948740	GOA
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	19948740	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12813029	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	12813029	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	18281285	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	20080667	GOA
enables protein phosphatase 2A binding	IDA IDA: Inferred from direct assay	20080667	GOA
enables protein serine/threonine kinase activator activity	IDA IDA: Inferred from direct assay	19903888	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	19903888	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	19903888	GOA
enables vascular endothelial growth factor receptor 2 binding	IPI IPI: Inferred from physical interaction	19033661	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to interleukin-1	IDA IDA: Inferred from direct assay	19948740	GOA
involved in cellular response to lipopolysaccharide	IDA IDA: Inferred from direct assay	19948740	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	12813029	GOA
involved in cellular response to vascular endothelial growth factor stimulus	IDA IDA: Inferred from direct assay	19033661	GOA
involved in extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	19903888	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	20080667	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20080667	GOA
involved in negative regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19903888	GOA
involved in negative regulation of G0 to G1 transition	IDA IDA: Inferred from direct assay	19903888	GOA
involved in negative regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	20154697	GOA
involved in negative regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	12813029	GOA
involved in negative regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	20154697	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	20154697	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	19033661	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15310755	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20080667	GOA
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	19903888	GOA
involved in negative regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	19033661	GOA
involved in negative regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	20080667	GOA
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	20154697	GOA
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	20154697	GOA
involved in negative regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	20080667	GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	19903888	GOA
involved in negative regulation of protein catabolic process	IDA IDA: Inferred from direct assay	19903888	GOA
involved in negative regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	20154697	GOA
involved in negative regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	19948740	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15310755	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20154697	GOA
involved in negative regulation of vascular endothelial growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19033661	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	17389591	GOA
involved in positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	12813029	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	19903888	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	17389591	GOA
involved in positive regulation of apoptotic signaling pathway	IDA IDA: Inferred from direct assay	19903888	GOA
involved in positive regulation of proteasomal protein catabolic process	IMP IMP: Inferred from mutant phenotype	20080667	GOA
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	20080667	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	18281285	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15310755	GOA
involved in protein catabolic process	IDA IDA: Inferred from direct assay	17389591	GOA
involved in regulation of cell cycle	IDA IDA: Inferred from direct assay	19903888	GOA
involved in regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	19948740	GOA
involved in tube formation	IMP IMP: Inferred from mutant phenotype	19033661	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of AIP1-IRE1 complex	IDA IDA: Inferred from direct assay	18281285	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15310755	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	19948740	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15310755	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAB2IP Protein Structure

RasGAP

DUF3498

0
200
400
600
800
1000
1189 a.a.

Protein Preferred Names	Protein Names
disabled homolog 2-interacting protein	ASK-interacting protein 1

DAB2IP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DAB2IP	Q5VWQ8	DAB2IP	Homo sapiens	Q5VWQ8	Anti Bait CoIP	12813029
Intra	DAB2IP	Q5VWQ8	GSK3B	Homo sapiens	P49841	Anti Bait CoIP	20080667
Intra	DAB2IP	Q5VWQ8	MAP3K5	Homo sapiens	Q99683	Y2H	12813029
Intra	DAB2IP	Q5VWQ8	MAP3K5	Homo sapiens	Q99683	Anti Bait CoIP	12813029
Intra	DAB2IP	Q5VWQ8	SMARCA2	Homo sapiens	P51531	Y2H Pooling	21653829
Intra	DAB2IP	Q5VWQ8	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	33961781
Intra	DAB2IP	Q5VWQ8	MAP3K5	Bos taurus	F1MXH6	Anti Bait CoIP	12813029

Cross: Cross-species interaction Intra: Intraspecies interaction

DAB2IP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810823	DAB2IP Antibody (YA10066)	WB	Human, Mouse

Related Diseases

Diseases	Alias
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Arteriosclerosis	Arteriosclerotic Vascular Disease
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Aortic Aneurysm, Familial Abdominal, 1	Abdominal Aortic Aneurysm Aortic Aneurysm, Familial Abdominal 1 Aneurysm, Abdominal Aortic AAA Aortic Aneurysm, Abdominal AAA1 Aortic Aneurysm, Familial Abdominal Aortic Aneurysm Abdominal Abdominal Aortic Aneurysms Abdominal Aortic Aneurysm Without Mention Of Perforation Or Rupture Abdomen Aneurysm Abdominal Aorta Aneurysm Aneurysm Of Abdominal Aorta Aortic Abdomen Aneurysm Aaa - [Abdominal Aortic Aneurysm] Abdominal Aneurysm Abdominal Aorta Aneurysm Rupture Abdominal Aorta Aneurysm Ruptured Abdominal Aortic Aneurysm Which Has Ruptured Ruptured Aaa Abdomen Aorta Aneurysm Ruptured Abdomen Aorta Rupture Abdomen Aortic Aneurysm Rupture Abdomen Aneurysm Rupture Abdomen Aortic Aneurysm Ruptured Abdomen Aortic Rupture Abdominal Aorta Rupture Abdominal Aortic Rupture Rupture Abdomen Aorta Aneurysm Rupture Abdominal Aortic Aneurysm Ruptured Abdomen Aneurysm Ruptured Abdomen Aorta Ruptured Abdomen Aortic Ruptured Abdominal Aneurysm Ruptured Abdominal Aorta Ruptured Abdominal Aortic Ruptured Aorta Abdominalis Aneurysm False Abdomen Aorta Aneurysm Ruptured False Abdominal Aortic Aneurysm Ruptured False Abdominal Aorta Aneurysm Ruptured False Abdomen Aortic Aneurysm Ruptured

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03512	DAB2IP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DAB2IP	RGD	RGD:621686
Mus musculus	DAB2IP	MGD	MGI:1916851
Felis catus	DAB2IP	VGNC	VGNC:61330
Bos taurus	DAB2IP	VGNC	VGNC:27866
Canis familiaris	DAB2IP	VGNC	VGNC:39760
Macaca mulatta	DAB2IP	VGNC	VGNC:71642
Others	DAB2IP	NCBI