Draxin - dorsal inhibitory axon guidance protein Gene

Also Known as neucrin; 2610109H07Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 70433

Summary

Involved in negative regulation of canonical Wnt signaling pathway; negative regulation of neuron projection development; and nervous system development. Acts upstream of or within negative regulation of axon extension and negative regulation of neuron apoptotic process. Located in extracellular region. Is expressed in several structures, including central nervous system; dorsal root ganglion; future brain; neural retina; and vibrissa. Orthologous to human DRAXIN (dorsal inhibitory axon guidance protein). [provided by Alliance of Genome Resources, Apr 2022]

Draxin Products (1)

mRNA	Protein	Name
NM_027426.3	NP_081702.2	draxin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19857465	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in anterior commissure morphogenesis	IMP IMP: Inferred from mutant phenotype	23206892	MGI
involved in axon guidance	IMP IMP: Inferred from mutant phenotype	19150847	MGI
involved in commissural neuron differentiation in spinal cord	IMP IMP: Inferred from mutant phenotype	19150847	MGI
involved in dorsal spinal cord development	IMP IMP: Inferred from mutant phenotype	19150847	MGI
involved in forebrain development	IMP IMP: Inferred from mutant phenotype	19150847	MGI
acts upstream of hippocampal neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	19808066	MGI
acts upstream of or within negative regulation of axon extension	IDA IDA: Inferred from direct assay	20621059	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	19857465	MGI
acts upstream of or within negative regulation of hippocampal neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	19808066	MGI
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	23206892	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	19808066	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	20621059	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
draxin	dorsal repulsive axon guidance protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03990	DRAXIN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21118	Draxin Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27637	Draxin Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Draxin	NCBI	NCBI:374946