DRAXIN - dorsal inhibitory axon guidance protein Gene

Also Known as UNQ3119; neucrin; AGPA3119; C1orf187

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 374946

About DRAXIN

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,686,635-11,725,857 (from NCBI)

This gene has 1 transcript (splice variant) and 198 orthologues. Low expression observed in reference dataset.

Summary

Predicted to be involved in negative regulation of canonical Wnt signaling pathway; negative regulation of neuron projection development; and nervous system development. Predicted to act upstream of or within negative regulation of axon extension and negative regulation of neuron apoptotic process. Predicted to be active in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

DRAXIN Products (1)

mRNA Protein Name
NM_198545.4 NP_940947.3 draxin precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
29503192 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26190107 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DRAXIN Protein Structure

Draxin

Draxin: Draxin (35 - 349)

  • 0
  • 100
  • 200
  • 300
  • 349 a.a.
Protein Preferred Names Protein Names

draxin

  • dorsal repulsive axon guidance protein

DRAXIN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DRAXIN Q8NBI3 NTN3 Homo sapiens O00634
AVEXIS
26190107
Intra
DRAXIN Q8NBI3 NTN1 Homo sapiens O95631
AVEXIS
26190107
Intra
DRAXIN Q8NBI3 NTN1 Homo sapiens O95631
SPR
26190107
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DRAXIN Proteins

Cat. No. Product Name Accession Purity
HY-P76878 Draxin Protein, Human (HEK293, His) Q8NBI3 (G26-V349) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Third Cranial Nerve Disease

  • Disorder Of Oculomotor Nerve

  • Oculomotor Nerve Disorder

  • Oculomotor Nerve Paralysis

  • Third Cranial Nerve Disorder
Mirror Movements 1

  • Congenital Mirror Movement Disorder

  • Bimanual Synergia

  • Congenital Mirror Movements

  • Familial Congenital Controlateral Synkinesia

  • Familial Congenital Mirror Movements

  • Hereditary Congenital Controlateral Synkinesia

  • Hereditary Congenital Mirror Movements

  • Isolated Congenital Controlateral Synkinesia

  • Isolated Congenital Mirror Movements

  • Mirror Movements

  • MRMV1

  • Mirror Movements 1 And/Or Agenesis Of The Corpus Callosum

  • Mirror Movements, Congenital

  • Bimanual Synkinesis

  • Cmm

  • Mirror Movements, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03990 DRAXIN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21118 Draxin Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27637 Draxin Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DRAXIN MGD MGI:1917683
Macaca mulatta DRAXIN VGNC VGNC:106352
Bos taurus DRAXIN VGNC VGNC:28204
Rattus norvegicus DRAXIN RGD RGD:1585098
Canis familiaris DRAXIN VGNC VGNC:40090
Felis catus DRAXIN VGNC VGNC:61622
Others DRAXIN NCBI