NTN3 - netrin 3 Gene

Also Known as NTN2L

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4917

About NTN3

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,471,297-2,474,145 (from NCBI)

This gene has 1 transcript (splice variant), 195 orthologues and 27 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable signaling receptor binding activity. Predicted to be involved in animal organ morphogenesis; neuron projection development; and tissue development. Predicted to be located in Golgi apparatus and extracellular region. Predicted to be active in basement membrane. [provided by Alliance of Genome Resources, Apr 2022]

NTN3 Products (1)

mRNA Protein Name
NM_006181.3 NP_006172.1 netrin-3 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
26190107 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTN3 Protein Structure

Laminin_N

Laminin_N: Laminin N-terminal (Domain VI) (40 - 253)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (255 - 298)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (311 - 366)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (374 - 416)

NTR

NTR: UNC-6/NTR/C345C module (457 - 570)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 580 a.a.
Protein Preferred Names Protein Names

netrin-3

  • Netrin-2, chicken, homolog of, like

NTN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NTN3 O00634 DRAXIN Homo sapiens Q8NBI3
AVEXIS
26190107
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Deafness, Autosomal Recessive 86

  • DFNB86

  • Autosomal Recessive Nonsyndromic Deafness 86

  • Autosomal Recessive Deafness 86

  • Deafness, Autosomal Recessive, 86

  • Deafness, Nonsyndromic, Autosomal Recessive, Type 86
Optic Nerve Hypoplasia, Bilateral

  • Optic Nerve Hypoplasia

  • Bilateral Optic Nerve Hypoplasia

  • Optic Nerve Hypoplasia, Familial Bilateral

  • Familial Bilateral Optic Nerve Hypoplasia

  • Isolated Optic Nerve Hypoplasia/Aplasia

  • Optic Nerve Aplasia, Bilateral

  • Onh

  • BONH

  • Bilateral Optic Nerve Aplasia

  • Hypoplasia, Optic Nerve, Bilateral
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09622 NTN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17412 Ntn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23866 Ntn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NTN3 VGNC VGNC:44008
Mus musculus NTN3 MGD MGI:1341188
Rattus norvegicus NTN3 RGD RGD:619811
Felis catus NTN3 VGNC VGNC:68577
Bos taurus NTN3 VGNC VGNC:32305
Macaca mulatta NTN3 VGNC VGNC:104741
Others NTN3 NCBI