Myh14 - myosin, heavy polypeptide 14 Gene

Also Known as II-C; NHMCII; NMHC II-C; 2400004E04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71960

Summary

Enables ATP binding activity; actin filament binding activity; and microfilament motor activity. Acts upstream of or within actin filament-based movement. Located in several cellular components, including brush border; growth cone; and stress fiber. Part of Myosin complex. Is expressed in several structures, including alimentary system; central nervous system; respiratory system; sensory organ; and vibrissa. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 4A and sensorineural hearing loss. Orthologous to human MYH14 (Myosin heavy chain 14). [provided by Alliance of Genome Resources, Apr 2022]

Myh14 Products (3)

mRNA Protein Name
NM_001271538.1 NP_001258467.1 myosin-14 isoform 1
NM_001271540.1 NP_001258469.1 myosin-14 isoform 2
NM_028021.3 NP_082297.1 myosin-14 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
15845534 MGI
enables actin filament binding IDA
IDA: Inferred from direct assay
14594953 MGI
enables microfilament motor activity IDA
IDA: Inferred from direct assay
14594953 MGI
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
19959848 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin filament-based movement IDA
IDA: Inferred from direct assay
14594953 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
15880105 MGI
located in brush border IDA
IDA: Inferred from direct assay
22114352 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15880105 MGI
located in growth cone IDA
IDA: Inferred from direct assay
15880105 MGI
part of myosin complex IDA
IDA: Inferred from direct assay
14594953 MGI
located in stress fiber IDA
IDA: Inferred from direct assay
15774463 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myosin-14

  • myosin heavy chain, non-muscle IIc

  • myosin, heavy chain 14

  • non-muscle myosin heavy chain IIc

  • nonmuscle myosin heavy chain

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08899 MYH14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08906 MYH7B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myh14 NCBI NCBI:79784