Mir98 - microRNA 98 Gene

Also Known as Mirn98; mir-98; mmu-mir-98

Species: Mus musculus

Gene Type: ncRNA
Gene ID: 723947

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
21609717 MGI
acts upstream of or within long-term synaptic potentiation IEP
IEP: Inferred from expression pattern
25858512 MGI
acts upstream of or within negative regulation of interleukin-10 production IDA
IDA: Inferred from direct assay
21609717 MGI
acts upstream of or within positive regulation of gene expression IDA
IDA: Inferred from direct assay
21609717 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir98 NCBI NCBI:407054