Ssbp3 - single-stranded DNA binding protein 3 Gene

Also Known as LAST; SSDP1; 2610021L12Rik; 2610200M23Rik; 5730488C10Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 72475

Summary

This gene encodes a member of the Ssdp (sequence-specific single-stranded DNA binding protein) family of proteins. The encoded protein binds specifically to single-stranded pyrimidine-rich DNA elements. The encoded protein has been shown to be important for head development and may play a role in the differentiation of spinal interneurons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Ssbp3 Products (3)

mRNA	Protein	Name
NM_001355532.1	NP_001342461.1	single-stranded DNA-binding protein 3 isoform c
NM_023672.2	NP_076161.2	single-stranded DNA-binding protein 3 isoform a
NM_198438.1	NP_940840.1	single-stranded DNA-binding protein 3 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19323994	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	19323994	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in head development	IGI IGI: Inferred from genetic interaction	15857913	MGI
involved in head morphogenesis	IMP IMP: Inferred from mutant phenotype	15857913	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	24029230	MGI
acts upstream of mesendoderm development	IMP IMP: Inferred from mutant phenotype	26494787	MGI
involved in midbrain-hindbrain boundary initiation	IMP IMP: Inferred from mutant phenotype	15857913	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	15857913	MGI
involved in positive regulation of anterior head development	IMP IMP: Inferred from mutant phenotype	15857913	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15857913	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15857913	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	19323994	MGI
involved in prechordal plate formation	IMP IMP: Inferred from mutant phenotype	15857913	MGI
involved in protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	15857913	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	15857913	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	26494787	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
single-stranded DNA-binding protein 3	Lck-associated signal transducer sequence-specific single-stranded-DNA-binding protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13807	SSBP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ssbp3	NCBI	NCBI:23648