country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

TSPY1 - testis specific protein Y-linked 1 Gene

Also Known as CT78; TSPY; DYS14; pJA923

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7258

About TSPY1

Cytogenetic location: Yp11.2 Genomic coordinates (GRCh38): Y:9,466,955-9,469,749 (from NCBI)

This gene has 2 transcripts (splice variants), 198 orthologues, 18 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 33.8).

Summary

The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Many functional paralogs and pseudogenes of this gene are present in a cluster in humans, but only a single, nonfunctional orthologous gene is found in mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

TSPY1 Products (3)

mRNA	Protein	Name
NM_001197242.2	NP_001184171.1	testis-specific Y-encoded protein 1 isoform TSPY-L
NM_001320964.2	NP_001307893.1	testis-specific Y-encoded protein 1 isoform 3
NM_003308.4	NP_003299.2	testis-specific Y-encoded protein 1 isoform TSPY-S

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18649364	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPY1 Protein Structure

NAP

0
100
200
308 a.a.

Protein Preferred Names	Protein Names
testis-specific Y-encoded protein 1	cancer/testis antigen 78

TSPY1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	TSPY1	Q01534	Eef1a1	Mus musculus	P10126	Confocal	18649364
Cross	TSPY1	Q01534	Eef1a1	Mus musculus	P10126	Anti Tag CoIP	18649364
Cross	TSPY1	Q01534	Eef1a1	Mus musculus	P10126	Pull Down	18649364
Cross	TSPY1	Q01534	Eef1a1	Mus musculus	P10126	Y2H	18649364

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Gonadoblastoma	GBY
Testicular Seminoma	Seminoma Of Testis Seminomatous Germ Cell Tumor Of Testis Testicular Seminomatous Germ Cell Tumor Seminoma
Partial Deletion Of Y	Partial Chromosome Y Deletion Partial Deletion Of Y Chromosome Short Arm Partial Deletion Of Chromosome Y Partial Deletion Of The Long Arm Of The Y Chromosome Y-Chromosome Microdeletions Male Sterility Due To Chromosome Y Deletion Y Chromosome Deletions
Sudden Infant Death With Dysgenesis Of The Testes Syndrome	SIDDT Sudden Infant Death-Dysgenesis Of The Testes Syndrome Sudden Infant Death - Dysgenesis Of The Testes
Turner Syndrome	Monosomy X Gonadal Dysgenesis Turner Type Ullrich-Turner Syndrome Bonnevie-Ullrich Syndrome Karyotype 45, X Genital Dwarfism, Turner Type Gonadal Dysgenesis 45,X Turner'S Syndrome Gonadal Dysgenesis - Turner Monosomy X Syndrome Xo Syndrome Genital Dwarfism 45, X Syndrome Bonnevie-Ulrich Syndrome Chromosome X Monosomy X Schereshevkii Turner Syndrome Turner Varny Syndrome Ts 45,X Syndrome 45,X/46,Xx Syndrome Turners Syndrome Gonadal Dysgenesis, 45,X X0 Syndrome
Seminoma	Seminoma, Pure
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15180	TSPY1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TSPY1	RGD	RGD:3912