TSPY1 - testis specific protein Y-linked 1 Gene

Homo sapiens

Also known as CT78; TSPY; DYS14; pJA923

Gene ID: 7258 | Gene type: protein coding

About TSPY1

Cytogenetic location: Yp11.2 Genomic coordinates (GRCh38): Y:9,466,955-9,469,749 (from NCBI)

This gene has 2 transcripts (splice variants), 198 orthologues, 18 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 33.8).

Summary

The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Many functional paralogs and pseudogenes of this gene are present in a cluster in humans, but only a single, nonfunctional orthologous gene is found in mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

TSPY1 Products(3)

mRNA	Protein	Name
NM_001197242.2	NP_001184171.1	testis-specific Y-encoded protein 1 isoform TSPY-L
NM_001320964.2	NP_001307893.1	testis-specific Y-encoded protein 1 isoform 3
NM_003308.4	NP_003299.2	testis-specific Y-encoded protein 1 isoform TSPY-S

TSPY1 Protein Structure

NAP

0
100
200
308 a.a.

Protein Preferred Names

Protein Names

testis-specific Y-encoded protein 1

cancer/testis antigen 78

Related Diseases

Diseases

Alias

Gonadoblastoma

GBY

Testicular Seminoma

Seminoma Of Testis	Seminomatous Germ Cell Tumor Of Testis
Testicular Seminomatous Germ Cell Tumor	Seminoma

Partial Deletion Of Y

Partial Chromosome Y Deletion	Partial Deletion Of Y Chromosome Short Arm
Partial Deletion Of Chromosome Y	Partial Deletion Of The Long Arm Of The Y Chromosome
Y-Chromosome Microdeletions	Male Sterility Due To Chromosome Y Deletion
Y Chromosome Deletions

Sudden Infant Death With Dysgenesis Of The Testes Syndrome

SIDDT	Sudden Infant Death-Dysgenesis Of The Testes Syndrome
Sudden Infant Death - Dysgenesis Of The Testes

Turner Syndrome

Monosomy X	Gonadal Dysgenesis Turner Type
Ullrich-Turner Syndrome	Bonnevie-Ullrich Syndrome
Karyotype 45, X	Genital Dwarfism, Turner Type
Gonadal Dysgenesis	45,X
Turner'S Syndrome	Gonadal Dysgenesis - Turner
Monosomy X Syndrome	Xo Syndrome
Genital Dwarfism	45, X Syndrome
Bonnevie-Ulrich Syndrome	Chromosome X Monosomy X
Schereshevkii Turner Syndrome	Turner Varny Syndrome
Ts	45,X Syndrome
45,X/46,Xx Syndrome	Turners Syndrome
Gonadal Dysgenesis, 45,X	X0 Syndrome

Seminoma

Seminoma, Pure

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Testicular Cancer

Testis Cancer	Testicular Carcinoma
Testicular Neoplasms	Malignant Neoplasm Of Testis
Childhood Neoplasm Of The Testis	Neoplasm Of Testis
Pediatric Testicular Neoplasm	Testicular Tumor
Testis Neoplasm	Testicular Tumors
Testicular Neoplasm	Testicular Malignant Germ Cell Tumor
Childhood Testicular Neoplasm	Carcinoma Of The Testis
Cancer Of Testis	Malignant Neoplasm Of Testis, Nos
Malignant Neoplasm Of Testis, Unspecified	Malignant Tumour Of Testis
Testicle Cancer	Primary Malignant Neoplasm Of Testis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15180	TSPY1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TSPY1	RGD	RGD:3912

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