Slc17a7 - solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 Gene

Also Known as Vglut1; 2900052E22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72961

Summary

Enables extracellularly glutamate-gated Chloride Channel activity. Involved in neurotransmitter loading into synaptic vesicle. Acts upstream of or within several processes, including chemical synaptic transmission; long-term memory; and sequestering of neurotransmitter. Located in several cellular components, including cerebellar mossy fiber; excitatory synapse; and synaptic vesicle membrane. Is expressed in several structures, including brain; retina layer; and spinal cord dorsal horn. Orthologous to human SLC17A7 (solute carrier family 17 member 7). [provided by Alliance of Genome Resources, Apr 2022]

Slc17a7 Products (1)

mRNA Protein Name
NM_182993.2 NP_892038.2 vesicular glutamate transporter 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-glutamate uniporter activity IDA
IDA: Inferred from direct assay
25433636 MGI
enables chloride channel activity IDA
IDA: Inferred from direct assay
25433636 MGI
enables extracellularly glutamate-gated chloride channel activity IDA
IDA: Inferred from direct assay
19169251 MGI
enables phosphate ion uniporter activity IDA
IDA: Inferred from direct assay
29642010 MGI
enables sodium:phosphate symporter activity IDA
IDA: Inferred from direct assay
29642010 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within L-glutamate import IDA
IDA: Inferred from direct assay
15860731 MGI
acts upstream of or within L-glutamate import IGI
IGI: Inferred from genetic interaction
15860731 MGI
acts upstream of or within L-glutamate import IMP
IMP: Inferred from mutant phenotype
15118123 MGI
involved in L-glutamate transmembrane transport IDA
IDA: Inferred from direct assay
25433636 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
17611277 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
15118123 MGI
acts upstream of or within excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
15118123 MGI
acts upstream of or within long-term memory IMP
IMP: Inferred from mutant phenotype
17241289 MGI
acts upstream of or within maintenance of location in cell IMP
IMP: Inferred from mutant phenotype
15103023 MGI
involved in neurotransmitter loading into synaptic vesicle IDA
IDA: Inferred from direct assay
15118123 MGI
involved in neurotransmitter loading into synaptic vesicle IMP
IMP: Inferred from mutant phenotype
15118123 MGI
involved in phosphate ion homeostasis IDA
IDA: Inferred from direct assay
33440152 MGI
involved in phosphate ion transmembrane transport IDA
IDA: Inferred from direct assay
29642010 MGI
involved in phosphate ion transport IDA
IDA: Inferred from direct assay
29642010 MGI
acts upstream of or within sequestering of neurotransmitter IMP
IMP: Inferred from mutant phenotype
15103023 MGI
involved in sodium-dependent phosphate transport IDA
IDA: Inferred from direct assay
29642010 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
15118123 MGI
acts upstream of or within synaptic vesicle lumen acidification IMP
IMP: Inferred from mutant phenotype
19169251 MGI
Cellular Component GO Annotation Evidence References Source
located in cerebellar mossy fiber IDA
IDA: Inferred from direct assay
23791195 MGI
located in excitatory synapse IDA
IDA: Inferred from direct assay
16980967 MGI
located in presynaptic active zone IDA
IDA: Inferred from direct assay
18986540 MGI
located in synapse IDA
IDA: Inferred from direct assay
15118123 MGI
located in synaptic vesicle IDA
IDA: Inferred from direct assay
15579147 MGI
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
15860731 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vesicular glutamate transporter 1

  • brain-specific Na(+)-dependent inorganic phosphate cotransporter

  • solute carrier family 17 member 7

Slc17a7 Antibodies

Cat. No. Product Name Application Reactivity
HY-P87140 VGluT1 Antibody (YA6833) WB, IHC-P Mouse, Rat
HY-P87141 VGluT1 Antibody (YA6834) WB, IHC-P, IHC-F Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13040 SLC17A7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc17a7 NCBI NCBI:57030