2. Gene
  3. Wasl - WASP like actin nucleation promoting factor Gene

Wasl - WASP like actin nucleation promoting factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as N-WASP; 2900021I12Rik; 3110031I02Rik

Gene ID: 73178 | Gene type: protein coding

About Wasl

Summary

Predicted to enable cytoskeletal protein binding activity and identical protein binding activity. Involved in dendritic spine morphogenesis. Acts upstream of or within several processes, including actin Cytoskeleton organization; response to bacterium; and spindle localization. Located in actin cap and lamellipodium. Is expressed in brain; genitourinary system; liver; and spleen. Used to study atopic dermatitis. Orthologous to human WASL (WASP like actin nucleation promoting factor). [provided by Alliance of Genome Resources, Apr 2022]

Wasl Products(2)

mRNA Protein Name
NM_001167745.1 NP_001161217.1 actin nucleation-promoting factor WASL isoform 2
NM_028459.2 NP_082735.2 actin nucleation-promoting factor WASL isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11082044 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21874009 MGI
NOT acts upstream of or within cell projection assembly IMP
IMP: Inferred from mutant phenotype
11559594 MGI
involved in dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
25851601 MGI
acts upstream of or within protein-containing complex localization IMP
IMP: Inferred from mutant phenotype
21874009 MGI
involved in regulation of postsynapse organization IDA
IDA: Inferred from direct assay
25851601 MGI
involved in regulation of postsynapse organization IMP
IMP: Inferred from mutant phenotype
25851601 MGI
acts upstream of or within regulation of protein localization IMP
IMP: Inferred from mutant phenotype
22966049 MGI
acts upstream of or within response to bacterium IMP
IMP: Inferred from mutant phenotype
11559594 MGI
acts upstream of or within spindle localization IMP
IMP: Inferred from mutant phenotype
21874009 MGI
Cellular Component GO Annotation Evidence Reference Source
located in actin cap IDA
IDA: Inferred from direct assay
21874009 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
25851601 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25851601 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
15148305 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

actin nucleation-promoting factor WASL

neural Wiskott-Aldrich syndrome protein

Wiskott-Aldrich syndrome-like

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15747 WASL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wasl NCBI NCBI:8976