UCP1 - uncoupling protein 1 Gene

Also Known as UCP; SLC25A7

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7350

About UCP1

Cytogenetic location: 4q31.1 Genomic coordinates (GRCh38): 4:140,559,431-140,568,961 (from NCBI)

This gene has 1 transcript (splice variant), 168 orthologues and 49 paralogues. Low expression observed in reference dataset.

Summary

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate Oxidative Phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq, Jul 2008]

UCP1 Products (1)

mRNA	Protein	Name
NM_021833.5	NP_068605.1	mitochondrial brown fat uncoupling protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables long-chain fatty acid binding	IDA IDA: Inferred from direct assay	28781081	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables proton transmembrane transporter activity	IDA IDA: Inferred from direct assay	28781081	GOA
enables transmembrane transporter activity	IDA IDA: Inferred from direct assay	24196960	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in proton transmembrane transport	IDA IDA: Inferred from direct assay	24196960	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	9054939	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	9054939	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCP1 Protein Structure

Mito_carr

0
100
200
307 a.a.

Protein Preferred Names	Protein Names
mitochondrial brown fat uncoupling protein 1	solute carrier family 25 member 7

UCP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UCP1	P25874	NME2P1	Homo sapiens	O60361	Anti Tag CoIP	28514442
Intra	UCP1	P25874	NME2P1	Homo sapiens	O60361	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

UCP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P86593	UCP1 Antibody (YA6285)	WB, IHC-P, ICC/IF, IP, ELISA	Mouse, Rat

Related Diseases

Diseases	Alias
Lipomatosis, Multiple Symmetric	Multiple Symmetric Lipomatosis Lipomatosis, Familial Benign Cervical Lipomatosis, Multiple Symmetrical Lipodystrophy, Cephalothoracic Benign Symmetrical Lipomatosis Madelung Disease Madelung'S Disease MSL Cervical Symmetrical Lipomatosis Launois-Bensaude'S Lipomatosis Madelung'S Neck Multiple Symmetrical Lipomatosis Familial Symmetric Lipomatosis Launois-Bensaude Syndrome Cephalothoracic Lipodystrophy Familial Benign Cervical Lipomatosis Launois-Bensaude Lipomatosis
Lipomatosis	Benign Symmetrical Lipomatosis
Liposarcoma Of Bone	Liposarcoma Of The Bone
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Glucose Intolerance	Glucose: Intolerance Glucose: Malabsorption Malabsorption Of Glucose Impaired Glucose Tolerance
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Leptin Deficiency Or Dysfunction	Morbid Obesity Obesity Due To Congenital Leptin Deficiency LEPD Congenital Leptin Deficiency Obesity, Morbid Obesity, Morbid, Due To Leptin Deficiency Severe Obesity Obesity, Morbid, Nonsyndromic 1 Leptin Deficiency Obesity, Severe, Due To Leptin Deficiency Leptin Morbid Obesity Due To Leptin Deficiency Obesity Morbid Leptin Dysfunction
Axillary Lipoma	Lipoma Of Axilla
Lipomatosis, Multiple	Lipoma Familial Multiple Lipomatosis Lipomatosis, Familial Multiple Benign Lipomatous Tumor Lipomatous Neoplasm Multiple Lipomatosis Fml Lipo Benign Tumor Of Adipose Tissue Lipomatous Tumor Tumor Of Adipose Tissue Neoplasms, Adipose Tissue Lipomas
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Acquired Metabolic Disease
Overnutrition
Diabetes Mellitus	Diabetes
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Congenital Generalized Lipodystrophy	Berardinelli-Seip Congenital Lipodystrophy Berardinelli-Seip Syndrome Brunzell Syndrome Bscl Generalized Lipodystrophy Lipodystrophy, Congenital Generalized Seip Syndrome Total Lipodystrophy Cgl Lipoatrophic Diabetes Lipodystrophy, Generalized, Congenital Familial Generalized Lipodystrophy Congenital Generalized Lipodystrophy Type 2 Lipoatrophic Diabetes Mellitus Familial Partial Lipodystrophy, Type 2
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107574	TC-E 5003		98.06%	Unkown
HY-N0704	Agrimol B		99.75%	Unkown
HY-110148	WWL113	Inhibitor	99.72%	Unkown
HY-N0260	Epmedin C		99.47%	Unkown
HY-P2917	Glycerol kinase, microorganism	Inhibitor	98.00%	Unkown
HY-135115	Oleuropein Aglycone	Inhibitor	98.46%	Unkown
HY-138207	N-Oleoyl-L-phenylalanine		99.4%	Unkown
HY-114557	NSC 90469		99.41%	Unkown
HY-129692	Withanone	Inhibitor	93.28%	Unkown
HY-133095	BML-260	Activator	99.65%	Unkown
HY-153813	Z16078526	Modulator	98.12%	Unkown
HY-148973	ZW290	Inhibitor	99.60%	Unkown
HY-RS16955	Ucp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-101824	NC-2100	Activator	/	Unkown
HY-11032	SM-350300		/	Unkown
HY-114557R	NSC 90469 (Standard)		/	Unkown
HY-139994	XN methyl pyrazole		/	Unkown
HY-176148	ZGL-18		/	Unkown
HY-183094	AM73		/	Unkown
HY-183095	AM79		/	Unkown
HY-183096	AM31		/	Unkown
HY-183097	AM89		/	Unkown
HY-186011	CPAG-1	Activator	/	Unkown
HY-RS15410	UCP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-153812	AST 7062601		/	Unkown
HY-RS23398	Ucp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UCP1	VGNC	VGNC:66798
Macaca mulatta	UCP1	VGNC	VGNC:78708
Mus musculus	UCP1	MGD	MGI:98894
Bos taurus	UCP1	VGNC	VGNC:36640
Rattus norvegicus	UCP1	RGD	RGD:3931
Others	UCP1	NCBI