2. Metabolic Enzyme/Protease
  3. PGC-1α
  4. AM89

AM89 is a PGC-1α1 stabilizer. AM89 activates the expression of PGC-1α1 target genes and induces the upregulation of Ucp1 gene expression. AM89 is applicable for the research of obesity and related metabolic disorders.

For research use only. We do not sell to patients.

AM89

AM89 Chemical Structure

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AM89 Related Antibodies

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Description

AM89 is a PGC-1α1 stabilizer. AM89 activates the expression of PGC-1α1 target genes and induces the upregulation of Ucp1 gene expression. AM89 is applicable for the research of obesity and related metabolic disorders[1].

In Vitro

AM89 (10 μM; 8 h) increases EGFP-PGC-1α1 fusion protein levels in stable HEK 293-EGFPmPGC-1α1 cells, with an EGFP intensity of 143.3%[1].
AM89 (10 μM; 8 h) induces Ucp1 gene expression 5-fold and modestly increases other PGC-1α1 target gene expression in fully differentiated mouse brown adipocytes[1].
AM89 (10 μM; 8 h) stabilizes endogenous PGC-1α1 protein in fully differentiated mouse brown adipocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AM89 Related Antibodies

Real Time qPCR[1]

Cell Line: fully differentiated immortalized mouse brown adipocytes
Concentration: 10 μM
Incubation Time: 8 h
Result: Induced a 5-fold increase in Ucp1 gene expression relative to DMSO-treated controls.
Induced small increases in the expression of other PGC-1α1 target genes including Tra2, Fsp27, Cytc, Tfam, Cpt1b, Esrra, Glut4, Prdm16, Pparg, and Sod1, though these increases were less pronounced than the Ucp1 induction.

Western Blot Analysis[1]

Cell Line: fully differentiated immortalized mouse brown adipocytes
Concentration: 10 μM
Incubation Time: 8 h
Result: Stabilized endogenous PGC-1α1 protein in brown adipocytes, with protein accumulation levels comparable to other validated PGC-1α1 stabilizers.
Molecular Weight

393.46

Formula

C22H19NO4S
SMILES

CC1C(/C=C2C(N(CC3=CC=C(OC)C=C3)C(S/2)=O)=O)=CC(C=CC=C4)=C4O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AM89 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM89AM 89AM-89PGC-1αPPARγ coactivator-1αHEK 293-EGFPmPGC-1α1 cellsmouse brown adipocytesUcp1PGC-1α1obesitymitochondrial respirationbrown adipocytesmetabolic disordersInhibitorinhibitorinhibit

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