ZW290

Cat. No.: HY-148973: FAQs
Data Sheet Handling Instructions

Molarity Calculator

ZW290 is a compound to activate brown adipose tissue (BAT) thermogenic function. ZW290 increases the expression of uncoupling Protein 1 (UCP1) protein and inhibits ATP synthesis in BAT.

For research use only. We do not sell to patients.

ZW290 Chemical Structure

CAS No. : 2411852-67-8

Size		Stock
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

ZW290 is a compound to activate brown adipose tissue (BAT) thermogenic function. ZW290 increases the expression of uncoupling Protein 1 (UCP1) protein and inhibits ATP synthesis in BAT^[1].

In Vitro

ZW290 in brown adipose tissue (BAT) induces nonshivering thermogenesis by limiting the oxidation of lipid droplet-derived fatty acids and increasing UCP1 protein levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ZW290 (25-100 mg/kg; oral gavage; once a day; for 7 days) notably decreases the size of lipid droplets in BAT and increased the content of mitochondria and the expression of UCP1 in brown adipose tissue (BAT) and white adipose tissue (WAT). ZW290 could prolong the overall survival of mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Kunming (KM) mice (20 g) keeping under acute cold exposure (-20°C)^[1]
Dosage:	25 mg/kg, 50 mg/kg, or 100 mg/kg
Administration:	Oral gavage; once a day; for 7 days
Result:	Notably decreased the size of lipid droplets in BAT and increased the content of mitochondria and the expression of UCP1 in BAT and WAT.

Molecular Weight

414.43

Formula

C₂₀H₁₈N₂O₆S

CAS No.

2411852-67-8

SMILES

O=C1N(C2=CC=C(C=C2)OC)C(N/C1=C\C3=CC(OC)=C(C=C3)OCC(O)=O)=S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nan Wang, et al. ZW290 Increases Cold Tolerance by Inducing Thermogenesis via the Upregulation of Uncoupling Protein 1 in Brown Adipose Tissue In Vitro and In Vivo. Lipids. 2019 May;54(5):265-276. [Content Brief]

ZW290 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZW2902411852-67-8ZW 290ZW-290ATP Synthasethermogenic functionATP synthesisUCP1 proteinoralInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks