2. Gene
  3. Cby1 - chibby family member 1, beta catenin antagonist Gene

Cby1 - chibby family member 1, beta catenin antagonist Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CBY; arb1; Pgea1; PGEA14; 1110014P06Rik

Gene ID: 73739 | Gene type: protein coding

About Cby1

Summary

Predicted to enable beta-catenin binding activity and protein homodimerization activity. Involved in cardiac muscle cell differentiation and fat cell differentiation. Acts upstream of or within cilium assembly; floor plate development; and negative regulation of canonical Wnt signaling pathway. Located in centriole and ciliary basal body. Is expressed in heart; liver; lung; and olfactory epithelium. Used to study otitis media and primary ciliary dyskinesia. Orthologous to human CBY1 (chibby family member 1, beta catenin antagonist). [provided by Alliance of Genome Resources, Apr 2022]

Cby1 Products(1)

mRNA Protein Name
NM_028634.3 NP_082910.1 protein chibby homolog 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
29487109 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19364920 MGI
involved in cardiac muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
17261658 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
19364920 MGI
involved in fat cell differentiation IMP
IMP: Inferred from mutant phenotype
17403895 MGI
acts upstream of or within floor plate development IGI
IGI: Inferred from genetic interaction
29487109 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
19364920 MGI
Cellular Component GO Annotation Evidence Reference Source
located in centriole IDA
IDA: Inferred from direct assay
29487109 MGI
located in ciliary basal body IDA
IDA: Inferred from direct assay
19364920 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein chibby homolog 1

PIGEA-14

PKD2 interactor, Golgi and endoplasmic reticulum-associated 1

PKD2 interactor, golgi and endoplasmic reticulum associated 1

chibby homolog 1

cytosolic leucine-rich protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02016 CBY1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cby1 NCBI NCBI:25776