Thap1 - THAP domain containing, apoptosis associated protein 1 Gene

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; protein homodimerization activity; and zinc ion binding activity. Predicted to be involved in several processes, including endothelial cell proliferation; negative regulation of transcription by RNA polymerase II; and transcription, DNA-templated. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be active in nucleus. Is expressed in forelimb bud and genitourinary system. Used to study torsion dystonia 6. Human ortholog(s) of this gene implicated in torsion dystonia 6. Orthologous to human THAP1 (THAP domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]