Sash3 - SAM and SH3 domain containing 3 Gene

Mus musculus

Also known as SLY1; 1200013B08Rik

Gene ID: 74131 | Gene type: protein coding

About Sash3

Summary

Acts upstream of or within several processes, including positive regulation of gene expression; positive regulation of lymphocyte activation; and positive regulation of organ growth. Located in cytoplasm and nucleus. Is expressed in heart ventricle and thymus primordium. Orthologous to human SASH3 (SAM and SH3 domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Sash3 Products(2)

mRNA	Protein	Name
NM_001313749.1	NP_001300678.1	SAM and SH3 domain-containing protein 3 isoform 1
NM_028773.4	NP_083049.1	SAM and SH3 domain-containing protein 3 isoform 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell homeostasis	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of B cell proliferation	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of CD4-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of T cell cytokine production	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of or within homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of interleukin-4 production	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of or within positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of or within positive regulation of T cell cytokine production	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of or within positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of or within positive regulation of adaptive immune response	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of or within positive regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of or within positive regulation of interleukin-10 production	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of or within positive regulation of interleukin-2 production	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of or within positive regulation of interleukin-4 production	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of or within positive regulation of lymphocyte activation	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of or within positive regulation of organ growth	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of or within positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of or within positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16227612	MGI
acts upstream of type II interferon production	IMP IMP: Inferred from mutant phenotype	16227612	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16227612	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16227612	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

SAM and SH3 domain-containing protein 3

Novel SH3 and SAM domain containing protein

SH3 protein expressed in lymphocytes

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12453	SASH3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sash3	NCBI	NCBI:54440

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