Sash3 - SAM and SH3 domain containing 3 Gene

Also Known as SLY1; 1200013B08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74131

Summary

Acts upstream of or within several processes, including positive regulation of gene expression; positive regulation of lymphocyte activation; and positive regulation of organ growth. Located in cytoplasm and nucleus. Is expressed in heart ventricle and thymus primordium. Orthologous to human SASH3 (SAM and SH3 domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]

Sash3 Products (2)

mRNA Protein Name
NM_001313749.1 NP_001300678.1 SAM and SH3 domain-containing protein 3 isoform 1
NM_028773.4 NP_083049.1 SAM and SH3 domain-containing protein 3 isoform 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within B cell homeostasis IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of B cell proliferation IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of CD4-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of T cell cytokine production IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of T cell proliferation IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of or within homeostasis of number of cells within a tissue IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of interleukin-4 production IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of or within positive regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of or within positive regulation of CD4-positive, alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of or within positive regulation of T cell cytokine production IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of or within positive regulation of adaptive immune response IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of or within positive regulation of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of or within positive regulation of interleukin-10 production IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of or within positive regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of or within positive regulation of interleukin-4 production IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of or within positive regulation of lymphocyte activation IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of or within positive regulation of organ growth IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of or within positive regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
16227612 MGI
acts upstream of type II interferon production IMP
IMP: Inferred from mutant phenotype
16227612 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16227612 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16227612 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SAM and SH3 domain-containing protein 3

  • Novel SH3 and SAM domain containing protein

  • SH3 protein expressed in lymphocytes

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12453 SASH3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sash3 NCBI NCBI:54440