2. Gene
  3. Osbp2 - oxysterol binding protein 2 Gene

Osbp2 - oxysterol binding protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gm244; ORP-4; OSBPL1; 1700095P05Rik; C630001G20Rik

Gene ID: 74309 | Gene type: protein coding

About Osbp2

Summary

The protein encoded by this gene belongs to the oxysterol-binding protein-related family of proteins, which are defined by a C-terminal sterol domain with a highly conserved EQVSHHPP motif. Oxysterols are oxygenated derivatives of Cholesterol that are involved in mechanisms that include Apoptosis, Cholesterol homeostasis, lipid trafficking and cell differentiation. This protein is selectively expressed at high levels in the brain and testis. Within the testis, the mRNA is localized to postmeiotic germ cells, including spermatids and spermatozoa, but is not detectable in somatic cells. Mice homozygous mutant for a targeted deletion in this gene do not exhibit overt developmental phenotypes but are male sterile. Females display normal fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Osbp2 Products(5)

mRNA Protein Name
NM_001302630.2 NP_001289559.1 oxysterol-binding protein 2 isoform 3
NM_001302631.2 NP_001289560.1 oxysterol-binding protein 2 isoform 2
NM_001363163.1 NP_001350092.1 oxysterol-binding protein 2 isoform 4
NM_001363164.1 NP_001350093.1 oxysterol-binding protein 2 isoform 5
NM_152818.3 NP_690031.2 oxysterol-binding protein 2 isoform 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
24245814 MGI
Cellular Component GO Annotation Evidence Reference Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
24245814 MGI
located in apical dendrite IDA
IDA: Inferred from direct assay
24245814 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

oxysterol-binding protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09836 OSBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Osbp2 NCBI NCBI:23762