Spag17 - sperm associated antigen 17 Gene

Also Known as PF6; Spag17-ps; 4931427F14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74362

Summary

Acts upstream of or within axonemal central apparatus assembly and epithelial cilium movement involved in extracellular fluid movement. Located in axonemal central apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nasal cavity respiratory epithelium; respiratory system; and spinal cord. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human SPAG17 (sperm associated antigen 17). [provided by Alliance of Genome Resources, Apr 2022]

Spag17 Products (1)

mRNA Protein Name
NM_028892.4 NP_083168.3 sperm-associated antigen 17

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15827353 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axonemal central apparatus assembly IMP
IMP: Inferred from mutant phenotype
23418344 MGI
acts upstream of or within epithelial cilium movement involved in extracellular fluid movement IMP
IMP: Inferred from mutant phenotype
23418344 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
23418344 MGI
involved in intramanchette transport IMP
IMP: Inferred from mutant phenotype
29690537 MGI
involved in manchette assembly IMP
IMP: Inferred from mutant phenotype
29690537 MGI
involved in motile cilium assembly IMP
IMP: Inferred from mutant phenotype
32988999 MGI
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
29690537 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
29690537 MGI
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
29690537 MGI
located in axonemal central apparatus IDA
IDA: Inferred from direct assay
15827353 MGI
located in axonemal central apparatus IMP
IMP: Inferred from mutant phenotype
23418344 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
29690537 MGI
located in manchette IDA
IDA: Inferred from direct assay
29690537 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sperm-associated antigen 17

  • projection protein PF6 homolog

  • sperm associated antigen 17, pseudogene

Spag17 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Spag17 Q5S003 Spag6 Mus musculus Q9JLI7
Y2H
15827353
Intra
Spag17 Q5S003 Spag6 Mus musculus Q9JLI7
Anti Bait CoIP
15827353
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13622 SPAG17 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spag17 NCBI NCBI:200162