Spag17 - sperm associated antigen 17 Gene

Mus musculus

Also known as PF6; Spag17-ps; 4931427F14Rik

Gene ID: 74362 | Gene type: protein coding

About Spag17

Summary

Acts upstream of or within axonemal central apparatus assembly and epithelial cilium movement involved in extracellular fluid movement. Located in axonemal central apparatus. Is expressed in several structures, including alimentary system; genitourinary system; nasal cavity respiratory epithelium; respiratory system; and spinal cord. Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human SPAG17 (sperm associated antigen 17). [provided by Alliance of Genome Resources, Apr 2022]

Spag17 Products(1)

mRNA	Protein	Name
NM_028892.4	NP_083168.3	sperm-associated antigen 17

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15827353	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axonemal central apparatus assembly	IMP IMP: Inferred from mutant phenotype	23418344	MGI
acts upstream of or within epithelial cilium movement involved in extracellular fluid movement	IMP IMP: Inferred from mutant phenotype	23418344	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	23418344	MGI
involved in intramanchette transport	IMP IMP: Inferred from mutant phenotype	29690537	MGI
involved in manchette assembly	IMP IMP: Inferred from mutant phenotype	29690537	MGI
involved in motile cilium assembly	IMP IMP: Inferred from mutant phenotype	32988999	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	29690537	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	29690537	MGI
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	29690537	MGI
located in axonemal central apparatus	IDA IDA: Inferred from direct assay	15827353	MGI
located in axonemal central apparatus	IMP IMP: Inferred from mutant phenotype	23418344	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	29690537	MGI
located in manchette	IDA IDA: Inferred from direct assay	29690537	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sperm-associated antigen 17

projection protein PF6 homolog

sperm associated antigen 17, pseudogene

Spag17 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Spag17	Q5S003	Spag6	Mus musculus	Q9JLI7	Y2H	15827353
Intra	Spag17	Q5S003	Spag6	Mus musculus	Q9JLI7	Anti Bait CoIP	15827353

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13622	SPAG17 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spag17	NCBI	NCBI:200162

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