Clec16a - C-type lectin domain family 16, member A Gene

Also Known as curt; mKIAA0350; 4932416N17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 74374

Summary

Acts upstream of or within negative regulation of mitophagy; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of autophagosome maturation. Located in endolysosome membrane. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in Addison's disease; multiple sclerosis; rheumatoid arthritis; and type 1 diabetes mellitus. Orthologous to human CLEC16A (C-type lectin domain containing 16A). [provided by Alliance of Genome Resources, Apr 2022]

Clec16a Products (2)

mRNA Protein Name
NM_001204229.1 NP_001191158.1 protein CLEC16A isoform 2
NM_177562.5 NP_808230.2 protein CLEC16A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24949970 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of mitophagy IMP
IMP: Inferred from mutant phenotype
24949970 MGI
acts upstream of or within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
24949970 MGI
acts upstream of or within positive regulation of autophagosome maturation IMP
IMP: Inferred from mutant phenotype
24949970 MGI
acts upstream of proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
24949970 MGI
involved in protein destabilization IMP
IMP: Inferred from mutant phenotype
36822331 MGI
involved in regulation of proteasomal ubiquitin-dependent protein catabolic process IPI
IPI: Inferred from physical interaction
36822331 MGI
Cellular Component GO Annotation Evidence References Source
located in endolysosome membrane IDA
IDA: Inferred from direct assay
24949970 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein CLEC16A

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02784 CLEC16A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clec16a NCBI NCBI:23274