Specc1l - sperm antigen with calponin homology and coiled-coil domains 1-like Gene

Also Known as Cytsa; mKIAA0376; 4930470P14Rik; 4932439K10Rik; 9530057A13Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 74392

Summary

Enables beta-catenin binding activity. Acts upstream of or within several processes, including anterior neural tube closure; negative regulation of protein depolymerization; and positive regulation of protein kinase B signaling. Located in cell-cell junction; cytoplasm; and Cytoskeleton. Part of filamentous actin. Is expressed in 1st branchial arch maxillary component; branchial arch; eye; fronto-nasal process; and limb. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome type II and oblique facial clefting 1. Orthologous to human SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1 like). [provided by Alliance of Genome Resources, Apr 2022]

Specc1l Products (2)

mRNA	Protein	Name
NM_001145826.1	NP_001139298.1	cytospin-A isoform a
NM_153406.3	NP_700455.3	cytospin-A isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	26787558	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21703590	MGI
acts upstream of or within adherens junction organization	IMP IMP: Inferred from mutant phenotype	26787558	MGI
acts upstream of or within anterior neural tube closure	IMP IMP: Inferred from mutant phenotype	26787558	MGI
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	21703590	MGI
acts upstream of or within negative regulation of actin filament depolymerization	IDA IDA: Inferred from direct assay	21703590	MGI
acts upstream of or within negative regulation of microtubule depolymerization	IDA IDA: Inferred from direct assay	21703590	MGI
acts upstream of or within neural crest cell delamination	IMP IMP: Inferred from mutant phenotype	26787558	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	26787558	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	21703590	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	26787558	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	26787558	MGI
part of filamentous actin	IDA IDA: Inferred from direct assay	21703590	MGI
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	21703590	MGI
located in microtubule organizing center	IDA IDA: Inferred from direct assay	21703590	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cytospin-A	SPECC1-like protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13656	SPECC1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Specc1l	NCBI	NCBI:23384