2. Gene
  3. Specc1l - sperm antigen with calponin homology and coiled-coil domains 1-like Gene

Specc1l - sperm antigen with calponin homology and coiled-coil domains 1-like Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cytsa; mKIAA0376; 4930470P14Rik; 4932439K10Rik; 9530057A13Rik

Gene ID: 74392 | Gene type: protein coding

About Specc1l

Summary

Enables beta-catenin binding activity. Acts upstream of or within several processes, including anterior neural tube closure; negative regulation of protein depolymerization; and positive regulation of protein kinase B signaling. Located in cell-cell junction; cytoplasm; and Cytoskeleton. Part of filamentous actin. Is expressed in 1st branchial arch maxillary component; branchial arch; eye; fronto-nasal process; and limb. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome type II and oblique facial clefting 1. Orthologous to human SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1 like). [provided by Alliance of Genome Resources, Apr 2022]

Specc1l Products(2)

mRNA Protein Name
NM_001145826.1 NP_001139298.1 cytospin-A isoform a
NM_153406.3 NP_700455.3 cytospin-A isoform b
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
26787558 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21703590 MGI
acts upstream of or within adherens junction organization IMP
IMP: Inferred from mutant phenotype
26787558 MGI
acts upstream of or within anterior neural tube closure IMP
IMP: Inferred from mutant phenotype
26787558 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
21703590 MGI
acts upstream of or within negative regulation of actin filament depolymerization IDA
IDA: Inferred from direct assay
21703590 MGI
acts upstream of or within negative regulation of microtubule depolymerization IDA
IDA: Inferred from direct assay
21703590 MGI
acts upstream of or within neural crest cell delamination IMP
IMP: Inferred from mutant phenotype
26787558 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
26787558 MGI
Cellular Component GO Annotation Evidence Reference Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
21703590 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
26787558 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
26787558 MGI
part of filamentous actin IDA
IDA: Inferred from direct assay
21703590 MGI
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
21703590 MGI
located in microtubule organizing center IDA
IDA: Inferred from direct assay
21703590 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytospin-A

SPECC1-like protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13656 SPECC1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Specc1l NCBI NCBI:23384