Gle1 - GLE1 RNA export mediator (yeast) Gene

Predicted to enable several functions, including identical protein binding activity; inositol hexakisphosphate binding activity; and translation initiation factor binding activity. Predicted to be involved in mRNA export from nucleus; regulation of translational initiation; and regulation of translational termination. Predicted to act upstream of or within mRNA transport and protein transport. Predicted to be located in cytosol; microtubule organizing center; and nucleus. Predicted to be part of nuclear pore cytoplasmic filaments. Predicted to be active in cytoplasm. Is expressed in brain; cerebral cortex; and hippocampus. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 1. Orthologous to human GLE1 (GLE1 RNA export mediator). [provided by Alliance of Genome Resources, Apr 2022]