2. Gene
  3. Sppl3 - signal peptide peptidase 3 Gene

Sppl3 - signal peptide peptidase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Psl4; Usmg3; 4833416I09Rik

Gene ID: 74585 | Gene type: protein coding

About Sppl3

Summary

Predicted to enable aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of cytosolic calcium ion concentration. Located in endoplasmic reticulum-Golgi intermediate compartment membrane. Is expressed in central nervous system; gonad; retina; and vibrissa. Orthologous to human SPPL3 (signal peptide peptidase like 3). [provided by Alliance of Genome Resources, Apr 2022]

Sppl3 Products(1)

mRNA Protein Name
NM_029012.2 NP_083288.2 signal peptide peptidase-like 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25384971 MGI
Biological Process GO Annotation Evidence Reference Source
involved in T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
25384971 MGI
involved in positive regulation of calcineurin-NFAT signaling cascade IDA
IDA: Inferred from direct assay
25384971 MGI
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
25384971 MGI
involved in positive regulation of protein binding IDA
IDA: Inferred from direct assay
25384971 MGI
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum-Golgi intermediate compartment membrane IDA
IDA: Inferred from direct assay
25384971 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

signal peptide peptidase-like 3

IMP-2

SPP-like 3 protein

intramembrane protease 2

presenilin-like protein 4

upregulated during skeletal muscle growth 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13707 SPPL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sppl3 NCBI NCBI:121665