2. Gene
  3. SPPL3 - signal peptide peptidase like 3 Gene

SPPL3 - signal peptide peptidase like 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IMP2; PSH1; PSL4; PRO4332; MDHV1887

Gene ID: 121665 | Gene type: protein coding

About SPPL3

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,762,510-120,904,358 (from NCBI)

This gene has 9 transcripts (splice variants), 206 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 21.6), testis (RPKM 17.3) and 25 other tissues.

Summary

Enables aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of protein dephosphorylation. Located in Golgi-associated vesicle membrane; plasma membrane; and rough endoplasmic reticulum. Is integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

SPPL3 Products(1)

mRNA Protein Name
NM_139015.5 NP_620584.2 signal peptide peptidase-like 3

SPPL3 Protein Structure

Peptidase_A22B

Peptidase_A22B: Signal peptide peptidase (61 - 369)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
Protein Preferred Names Protein Names

signal peptide peptidase-like 3

SPP-like 3

Related Diseases

Diseases Alias
Plasmodium Ovale Malaria

Ovale Malaria

Malariaby Plasmodium Ovale
Sulfonamide Allergy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13707 SPPL3 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SPPL3 VGNC VGNC:80493
Bos taurus SPPL3 VGNC VGNC:35237
Macaca mulatta SPPL3 VGNC VGNC:81578
Rattus norvegicus SPPL3 RGD RGD:1562826
Canis familiaris SPPL3 VGNC VGNC:46761
Mus musculus SPPL3 MGD MGI:1891433