SPPL3 - signal peptide peptidase like 3 Gene

Also Known as IMP2; PSH1; PSL4; PRO4332; MDHV1887

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 121665

About SPPL3

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,762,510-120,904,358 (from NCBI)

This gene has 9 transcripts (splice variants), 206 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 21.6), testis (RPKM 17.3) and 25 other tissues.

Summary

Enables aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Involved in several processes, including T cell receptor signaling pathway; positive regulation of calcineurin-NFAT signaling cascade; and positive regulation of protein dephosphorylation. Located in Golgi-associated vesicle membrane; plasma membrane; and rough endoplasmic reticulum. Is integral component of cytoplasmic side of endoplasmic reticulum membrane and integral component of lumenal side of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

SPPL3 Products (1)

mRNA	Protein	Name
NM_139015.5	NP_620584.2	signal peptide peptidase-like 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables aspartic endopeptidase activity, intramembrane cleaving	IDA IDA: Inferred from direct assay	2313285	GOA
enables aspartic endopeptidase activity, intramembrane cleaving	IMP IMP: Inferred from mutant phenotype	16873890	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	2313285	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	15385547	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25384971	GOA
NOT involved in membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	16829952	GOA
involved in membrane protein proteolysis	IDA IDA: Inferred from direct assay	2313285	GOA
involved in positive regulation of calcineurin-NFAT signaling cascade	IMP IMP: Inferred from mutant phenotype	25384971	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi-associated vesicle membrane	IDA IDA: Inferred from direct assay	16829952	GOA
located in cytoplasmic side of endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	15385547	GOA
located in lumenal side of endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	15385547	GOA
located in membrane	IDA IDA: Inferred from direct assay	2313285	GOA
located in rough endoplasmic reticulum	IDA IDA: Inferred from direct assay	15998642	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPPL3 Protein Structure

Peptidase_A22B

0
100
200
300
384 a.a.

Protein Preferred Names	Protein Names
signal peptide peptidase-like 3	SPP-like 3

Related Diseases

Diseases	Alias
Plasmodium Ovale Malaria	Ovale Malaria Malariaby Plasmodium Ovale
Sulfonamide Allergy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13707	SPPL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SPPL3	VGNC	VGNC:80493
Bos taurus	SPPL3	VGNC	VGNC:35237
Macaca mulatta	SPPL3	VGNC	VGNC:81578
Rattus norvegicus	SPPL3	RGD	RGD:1562826
Canis familiaris	SPPL3	VGNC	VGNC:46761
Mus musculus	SPPL3	MGD	MGI:1891433
Others	SPPL3	NCBI