WNT9A - Wnt family member 9A Gene

Also Known as WNT14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7483

About WNT9A

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:227,918,656-227,947,932 (from NCBI)

This gene has 1 transcript (splice variant), 216 orthologues and 18 paralogues. Broad expression in heart (RPKM 3.6), endometrium (RPKM 2.9) and 21 other tissues.

Summary

The Wnt gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the Wnt gene family. It is expressed in gastric Cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region. [provided by RefSeq, Jul 2008]

WNT9A Products (1)

mRNA Protein Name
NM_003395.4 NP_003386.1 protein Wnt-9a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables receptor ligand activity IDA
IDA: Inferred from direct assay
28733458 GOA
Biological Process GO Annotation Evidence References Source
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
28733458 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17351820 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT9A Protein Structure

wnt

wnt: wnt family (62 - 364)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
Protein Preferred Names Protein Names

protein Wnt-9a

  • wingless-type MMTV integration site family, member 14

WNT9A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WNT9A O14904 ZBTB14 Homo sapiens O43829
Y2H Prey Pooling
32296183
Intra
WNT9A O14904 ZBTB14 Homo sapiens O43829
Validated Y2H
32296183
Intra
WNT9A O14904 ZBTB14 Homo sapiens O43829
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mullerian Aplasia And Hyperandrogenism

  • Mullerian Duct Failure And Hyperandrogenism

  • Wnt4 Deficiency

  • Müllerian Aplasia And Hyperandrogenism

  • Biason-Lauber Syndrome

  • Mayer-Rokitansky-Küster-Hauser-Biason-Lauber Syndrome

  • Mayer-Rokitansky-Küster-Hauser-Like Syndrome

  • Müllerian Duct Failure

  • Wnt4 Müllerian Aplasia

  • Wnt4 Müllerian Aplasia And Ovarian Dysfunction

  • MULLAPL

  • Wnt4 Mullerian Aplasia And Ovarian Dysfunction
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Norrie Disease

  • Atrophia Bulborum Hereditaria

  • Episkopi Blindness

  • Pseudoglioma

  • ND

  • Norrie-Warburg Disease

  • Anderson-Warburg Syndrome

  • Fetal Iritis Syndrome

  • Norrie Syndrome

  • Norrie-Warburg Syndrome

  • Ndp

  • Congenital Progressive Oculo-Acoustico-Cerebral Degeneration

  • Norrie'S Disease

  • Oligophrenia Microphthalmus

  • Pseudoglioma Congenita

  • Whitnall-Norman Syndrome
Proximal Symphalangism

  • Cushing'S Symphalangism

  • Symphalangism, Proximal

  • Hereditary Absence Of Proximal Interphalangeal Joints

  • Strasburger-Hawkins-Eldridge Syndrome

  • Strasburger-Hawkins-Eldridge-Hargrave-Mckusick Syndrome

  • Symphalangism, Proximal, 1a

  • Symphalangism, Proximal, 1b

  • Vessel'S Syndrome

  • Symphalangism, Cushing Type
Exudative Vitreoretinopathy

  • Familial Exudative Vitreoretinopathy

  • Fevr

  • Criswick-Schepens Syndrome

  • Exudative Vitreoretinopathy, Familial

  • Vitreoretinopathy, Exudative )

  • Exudative Vitreoretinopathy 1
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Robinow Syndrome

  • Acral Dysostosis With Facial And Genital Abnormalities

  • Fetal Face Syndrome

  • Robinow Dwarfism

  • Mesomelic Dwarfism-Small Genitalia Syndrome

  • Robinow-Silverman-Smith Syndrome

  • Costovertebral Segmentation Defect With Mesomelia

  • Covesdem Syndrome

  • Robinow'S Syndrome

  • Robinow-Silverman Syndrome
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15844 WNT9A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris WNT9A VGNC VGNC:54801
Rattus norvegicus WNT9A RGD RGD:1305018
Bos taurus WNT9A VGNC VGNC:36966
Macaca mulatta WNT9A VGNC VGNC:78796
Mus musculus WNT9A MGD MGI:2446084
Felis catus WNT9A VGNC VGNC:102363