Mei4 - meiotic double-stranded break formation protein 4 Gene

Mus musculus

Also known as 4930486G11Rik

Gene ID: 75033 | Gene type: protein coding

About Mei4

Summary

Involved in meiotic DNA double-strand break formation. Acts upstream of or within homologous chromosome pairing at meiosis; oogenesis; and spermatogenesis. Located in lateral element. Is expressed in spermatocyte. Orthologous to human MEI4 (meiotic double-stranded break formation protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Mei4 Products(3)

mRNA	Protein	Name
NM_001357477.1	NP_001344406.1	meiosis-specific protein MEI4 isoform 2
NM_001357479.1	NP_001344408.1	meiosis-specific protein MEI4 isoform 3
NM_175213.4	NP_780422.1	meiosis-specific protein MEI4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20551173	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within homologous chromosome pairing at meiosis	IMP IMP: Inferred from mutant phenotype	20551173	MGI
involved in meiotic DNA double-strand break formation	IMP IMP: Inferred from mutant phenotype	20551173	MGI
acts upstream of or within oogenesis	IMP IMP: Inferred from mutant phenotype	20551173	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	20551173	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome	IDA IDA: Inferred from direct assay	30569039	MGI
located in lateral element	IDA IDA: Inferred from direct assay	20551173	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

meiosis-specific protein MEI4

UPF0623 protein

meiosis-specific, MEI4 homolog

Mei4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Mei4	Q8BRM6	Rec114	Mus musculus	Q9CWH4	Y2H	20551173
Intra	Mei4	Q8BRM6	Rec114	Mus musculus	Q9CWH4	Anti Tag CoIP	20551173

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08320	MEI4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mei4	NCBI	NCBI:101928601

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