Mei4 - meiotic double-stranded break formation protein 4 Gene

Also Known as 4930486G11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75033

Summary

Involved in meiotic DNA double-strand break formation. Acts upstream of or within homologous chromosome pairing at meiosis; oogenesis; and spermatogenesis. Located in lateral element. Is expressed in spermatocyte. Orthologous to human MEI4 (meiotic double-stranded break formation protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Mei4 Products (3)

mRNA Protein Name
NM_001357477.1 NP_001344406.1 meiosis-specific protein MEI4 isoform 2
NM_001357479.1 NP_001344408.1 meiosis-specific protein MEI4 isoform 3
NM_175213.4 NP_780422.1 meiosis-specific protein MEI4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20551173 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within homologous chromosome pairing at meiosis IMP
IMP: Inferred from mutant phenotype
20551173 MGI
involved in meiotic DNA double-strand break formation IMP
IMP: Inferred from mutant phenotype
20551173 MGI
acts upstream of or within oogenesis IMP
IMP: Inferred from mutant phenotype
20551173 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
20551173 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome IDA
IDA: Inferred from direct assay
30569039 MGI
located in lateral element IDA
IDA: Inferred from direct assay
20551173 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

meiosis-specific protein MEI4

  • UPF0623 protein

  • meiosis-specific, MEI4 homolog

Mei4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Mei4 Q8BRM6 Rec114 Mus musculus Q9CWH4
Y2H
20551173
Intra
Mei4 Q8BRM6 Rec114 Mus musculus Q9CWH4
Anti Tag CoIP
20551173
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08320 MEI4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mei4 NCBI NCBI:101928601