Meiob - meiosis specific with OB domains Gene

Mus musculus

Also known as MLZ-675; 4930528F23Rik

Gene ID: 75178 | Gene type: protein coding

About Meiob

Summary

Enables chromatin binding activity; single-stranded DNA 3'-5' exodeoxyribonuclease activity; and single-stranded DNA binding activity. Involved in double-strand break repair via homologous recombination; fertilization; and meiosis I. Acts upstream of or within male meiotic nuclear division. Located in cytoplasm. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in spermatogenic failure 22. Orthologous to human MEIOB (meiosis specific with OB-fold). [provided by Alliance of Genome Resources, Apr 2022]

Meiob Products(1)

mRNA	Protein	Name
NM_029197.1	NP_083473.1	meiosis-specific with OB domain-containing protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	24068956	MGI
enables chromatin binding	IMP IMP: Inferred from mutant phenotype	24240703	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24240703	MGI
enables single-stranded DNA 3'-5' DNA exonuclease activity	IDA IDA: Inferred from direct assay	24240703	MGI
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	24068956	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	24068956	MGI
involved in female meiosis I	IMP IMP: Inferred from mutant phenotype	24068956	MGI
involved in fertilization	IMP IMP: Inferred from mutant phenotype	24068956	MGI
involved in homologous chromosome pairing at meiosis	IMP IMP: Inferred from mutant phenotype	24068956	MGI
involved in male meiosis I	IMP IMP: Inferred from mutant phenotype	24068956	MGI
involved in male meiotic nuclear division	IEP IEP: Inferred from expression pattern	20339383	MGI
involved in resolution of meiotic recombination intermediates	IMP IMP: Inferred from mutant phenotype	24068956	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20339383	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

meiosis-specific with OB domain-containing protein

protein expressed in male leptotene and zygotene spermatocytes 675

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08323	MEIOB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Meiob	NCBI	NCBI:254528

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