Meiob - meiosis specific with OB domains Gene

Also Known as MLZ-675; 4930528F23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75178

Summary

Enables chromatin binding activity; single-stranded DNA 3'-5' exodeoxyribonuclease activity; and single-stranded DNA binding activity. Involved in double-strand break repair via homologous recombination; fertilization; and meiosis I. Acts upstream of or within male meiotic nuclear division. Located in cytoplasm. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in spermatogenic failure 22. Orthologous to human MEIOB (meiosis specific with OB-fold). [provided by Alliance of Genome Resources, Apr 2022]

Meiob Products (1)

mRNA Protein Name
NM_029197.1 NP_083473.1 meiosis-specific with OB domain-containing protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
24068956 MGI
enables chromatin binding IMP
IMP: Inferred from mutant phenotype
24240703 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24240703 MGI
enables single-stranded DNA 3'-5' DNA exonuclease activity IDA
IDA: Inferred from direct assay
24240703 MGI
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
24068956 MGI
Biological Process GO Annotation Evidence References Source
involved in double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
24068956 MGI
involved in female meiosis I IMP
IMP: Inferred from mutant phenotype
24068956 MGI
involved in fertilization IMP
IMP: Inferred from mutant phenotype
24068956 MGI
involved in homologous chromosome pairing at meiosis IMP
IMP: Inferred from mutant phenotype
24068956 MGI
involved in male meiosis I IMP
IMP: Inferred from mutant phenotype
24068956 MGI
involved in male meiotic nuclear division IEP
IEP: Inferred from expression pattern
20339383 MGI
involved in resolution of meiotic recombination intermediates IMP
IMP: Inferred from mutant phenotype
24068956 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
20339383 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

meiosis-specific with OB domain-containing protein

  • protein expressed in male leptotene and zygotene spermatocytes 675

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08323 MEIOB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Meiob NCBI NCBI:254528