Sesn3 - sestrin 3 Gene

Also Known as SEST3; 5630400E15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75747

Summary

Predicted to enable leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Involved in several processes, including TORC2 signaling; glucose homeostasis; and regulation of signal transduction. Acts upstream of or within regulation of protein kinase B signaling. Part of TORC2 complex. Orthologous to human SESN3 (sestrin 3). [provided by Alliance of Genome Resources, Apr 2022]

Sesn3 Products (1)

mRNA Protein Name
NM_030261.4 NP_084537.2 sestrin-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25259925 MGI
Biological Process GO Annotation Evidence References Source
involved in TORC2 signaling IMP
IMP: Inferred from mutant phenotype
25377878 MGI
involved in cellular response to amino acid stimulus IMP
IMP: Inferred from mutant phenotype
25259925 MGI
acts upstream of or within glucose homeostasis IGI
IGI: Inferred from genetic interaction
22958918 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
25377878 MGI
involved in negative regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
25259925 MGI
involved in regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25377878 MGI
acts upstream of or within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
22958918 MGI
acts upstream of or within response to insulin IGI
IGI: Inferred from genetic interaction
22958918 MGI
involved in response to insulin IMP
IMP: Inferred from mutant phenotype
25377878 MGI
Cellular Component GO Annotation Evidence References Source
part of TORC2 complex IDA
IDA: Inferred from direct assay
25377878 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sestrin-3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175352 Nurr1 agonist 14 99.42% Unkown
HY-RS12736 SESN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21753 Sesn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28271 Sesn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sesn3 NCBI NCBI:143686