Senp2 - SUMO/sentrin specific peptidase 2 Gene

Also Known as SuPr-1; Smt3ip2; mKIAA1331; 2310007L05Rik; 4930538C18Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 75826

Summary

Enables SUMO-specific isopeptidase activity. Involved in fat cell differentiation and protein desumoylation. Acts upstream of or within several processes, including embryonic placenta development; negative regulation of DNA damage response, signal transduction by p53 class mediator; and regulation of cell cycle process. Located in cytoplasmic vesicle and nuclear body. Colocalizes with PML body. Is expressed in several structures, including blastocyst; central nervous system; early embryo; extraembryonic component; and retina. Orthologous to human SENP2 (SUMO specific peptidase 2). [provided by Alliance of Genome Resources, Apr 2022]

Senp2 Products (2)

mRNA	Protein	Name
NM_001357424.1	NP_001344353.1	sentrin-specific protease 2 isoform 2
NM_029457.3	NP_083733.1	sentrin-specific protease 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables deSUMOylase activity	IDA IDA: Inferred from direct assay	12419228	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in fat cell differentiation	IDA IDA: Inferred from direct assay	20194620	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	20417598	MGI
acts upstream of or within labyrinthine layer development	IMP IMP: Inferred from mutant phenotype	19090619	MGI
acts upstream of or within negative regulation of chromatin binding	IMP IMP: Inferred from mutant phenotype	20417598	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	20417598	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20417598	MGI
acts upstream of or within protein desumoylation	IDA IDA: Inferred from direct assay	15767674	MGI
involved in protein desumoylation	IDA IDA: Inferred from direct assay	12419228	MGI
acts upstream of or within protein desumoylation	IMP IMP: Inferred from mutant phenotype	20417598	MGI
acts upstream of or within regulation of DNA endoreduplication	IMP IMP: Inferred from mutant phenotype	19090619	MGI
acts upstream of or within regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	19090619	MGI
acts upstream of or within spongiotrophoblast layer development	IMP IMP: Inferred from mutant phenotype	19090619	MGI
acts upstream of or within trophoblast giant cell differentiation	IMP IMP: Inferred from mutant phenotype	19090619	MGI

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with PML body	IDA IDA: Inferred from direct assay	12419228	MGI
located in nuclear body	IDA IDA: Inferred from direct assay	20417598	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sentrin-specific protease 2	SUMO-1 protease-1 SUMO-1/Smt3-specific isopeptidase 2 SUMO/sentrin specific protease 2 axam2 sentrin/SUMO-specific protease SENP2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100708	NSC632839	Inhibitor	98.12%	Unkown
HY-151358	SENP2-IN-1	Inhibitor	98.05%	Unkown
HY-RS14025	SUMO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12672	SENP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18079	Senp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24554	Senp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Senp2	NCBI	NCBI:59343