Dock11 - dedicator of cytokinesis 11 Gene

Also Known as sph238; Zizimin2; 8030476J24; 5033414A21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 75974

Summary

Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including marginal zone B cell differentiation; positive regulation of GTPase activity; and positive regulation of filopodium assembly. Is expressed in brain; female reproductive system; gut; skin; and spleen. Orthologous to human DOCK11 (dedicator of cytokinesis 11). [provided by Alliance of Genome Resources, Apr 2022]

Dock11 Products (1)

mRNA Protein Name
NM_001009947.3 NP_001009947.2 dedicator of cytokinesis protein 11

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
15710388 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
15710388 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell homeostasis IMP
IMP: Inferred from mutant phenotype
25729399 MGI
involved in marginal zone B cell differentiation IMP
IMP: Inferred from mutant phenotype
25729399 MGI
involved in positive regulation of GTPase activity IDA
IDA: Inferred from direct assay
22494997 MGI
involved in positive regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
22494997 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 11

  • ACG

  • activated Cdc42-associated guanine nucleotide exchange factor

  • spleen specific 238 kDa protein with PH domain

  • zizimin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03923 DOCK11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dock11 NCBI NCBI:139818