DOCK11 - dedicator of cytokinesis 11 Gene

Also Known as ACG; ZIZ2; bB128O4.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 139818

About DOCK11

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:118,495,815-118,686,147 (from NCBI)

This gene has 4 transcripts (splice variants), 226 orthologues and 10 paralogues. Broad expression in fat (RPKM 20.0), lymph node (RPKM 11.7) and 19 other tissues.

Summary

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including marginal zone B cell differentiation; positive regulation of GTPase activity; and positive regulation of filopodium assembly. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

DOCK11 Products (1)

mRNA Protein Name
NM_144658.4 NP_653259.3 dedicator of cytokinesis protein 11

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25074804 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of filopodium assembly IMP
IMP: Inferred from mutant phenotype
37342957 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOCK11 Protein Structure

DUF3398

DUF3398: Domain of unknown function (DUF3398) (51 - 145)

PH

PH: PH domain (166 - 271)

DOCK-C2

DOCK-C2: C2 domain in Dock180 and Zizimin proteins (635 - 827)

DHR-2

DHR-2: Dock homology region 2 (1852 - 2028)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2073 a.a.
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 11

  • Activated Cdc42-associated guanine nucleotide exchange factor, ACG

Related Diseases

Diseases Alias
Viral Laryngitis
Brachydactyly, Type C

  • Brachydactyly Type C

  • BDC

  • Brachydactyly Haws Type

  • Brachydactyly, Haws Type

  • Brachydactyly C
Shoulder Impingement Syndrome

  • Impingement Syndrome Of Shoulder Region

  • Subacromial Impingement
Immunodeficiency 40

  • Dock2 Deficiency

  • IMD40

  • Immunodeficiency, Type 40
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03923 DOCK11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DOCK11 VGNC VGNC:40045
Felis catus DOCK11 VGNC VGNC:97404
Mus musculus DOCK11 MGD MGI:1923224
Bos taurus DOCK11 VGNC VGNC:28156
Rattus norvegicus DOCK11 RGD RGD:1564707
Macaca mulatta DOCK11 VGNC VGNC:71890
Others DOCK11 NCBI