2. Gene
  3. Arfrp1 - ADP-ribosylation factor related protein 1 Gene

Arfrp1 - ADP-ribosylation factor related protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 1500006I01Rik

Gene ID: 76688 | Gene type: protein coding

About Arfrp1

Summary

The gene encodes a membrane-associated GTPase that is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. It plays an essential role in Golgi function controlling recruitment of GRIP domain proteins and ARL1 to the trans-Golgi and trans-Golgi to plasma membrane trafficking of cell surface proteins such as E-cadherin. Deletion of this gene in mice leads to embryonic lethality during early gastrulation, which is at least partly caused by the disruption of E-cadherin trafficking to the cell surface and therefore lack of sufficient cell-cell adhesion in the embryo. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Arfrp1 Products(4)

mRNA Protein Name
NM_001165991.1 NP_001159463.1 ADP-ribosylation factor-related protein 1 isoform 1
NM_001165992.1 NP_001159464.1 ADP-ribosylation factor-related protein 1 isoform 1
NM_001165995.1 NP_001159467.1 ADP-ribosylation factor-related protein 1 isoform 2
NM_029702.4 NP_083978.3 ADP-ribosylation factor-related protein 1 isoform 1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within gastrulation IMP
IMP: Inferred from mutant phenotype
11839814 MGI
Cellular Component GO Annotation Evidence Reference Source
located in membrane IDA
IDA: Inferred from direct assay
11839814 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ADP-ribosylation factor-related protein 1

ARF-related protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00906 ARFRP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arfrp1 NCBI NCBI:10139