Ago4 - argonaute RISC catalytic subunit 4 Gene

Mus musculus

Also known as Eif2c4; 5730550L01Rik

Gene ID: 76850 | Gene type: protein coding

About Ago4

Summary

Enables RNA binding activity. Acts upstream of or within several processes, including male gonad development; meiotic nuclear division; and miRNA metabolic process. Located in P-body and nucleus. Part of RISC complex. Is expressed in several structures, including brain; lung; neural tube; tooth; and vibrissa. Orthologous to human AGO4 (argonaute RISC component 4). [provided by Alliance of Genome Resources, Apr 2022]

Ago4 Products(1)

mRNA	Protein	Name
NM_153177.3	NP_694817.2	protein argonaute-4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	19536157	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within male gonad development	IMP IMP: Inferred from mutant phenotype	22863743	MGI
acts upstream of or within male meiotic nuclear division	IMP IMP: Inferred from mutant phenotype	22863743	MGI
acts upstream of or within miRNA metabolic process	IMP IMP: Inferred from mutant phenotype	22863743	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22863743	MGI
acts upstream of or within regulation of cell morphogenesis	IMP IMP: Inferred from mutant phenotype	22863743	MGI
acts upstream of or within synaptonemal complex assembly	IMP IMP: Inferred from mutant phenotype	22863743	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in P-body	IDA IDA: Inferred from direct assay	19898466	MGI
part of RISC complex	IDA IDA: Inferred from direct assay	19536157	MGI
located in nucleus	IDA IDA: Inferred from direct assay	22863743	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein argonaute-4

Piwi/Argonaute family protein meIF2C4	argonaute 4
argonaute RISC catalytic component 4	eukaryotic translation initiation factor 2C, 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00455	AGO4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ago4	NCBI	NCBI:192670

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