Ago4 - argonaute RISC catalytic subunit 4 Gene

Also Known as Eif2c4; 5730550L01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 76850

Summary

Enables RNA binding activity. Acts upstream of or within several processes, including male gonad development; meiotic nuclear division; and miRNA metabolic process. Located in P-body and nucleus. Part of RISC complex. Is expressed in several structures, including brain; lung; neural tube; tooth; and vibrissa. Orthologous to human AGO4 (argonaute RISC component 4). [provided by Alliance of Genome Resources, Apr 2022]

Ago4 Products (1)

mRNA Protein Name
NM_153177.3 NP_694817.2 protein argonaute-4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
19536157 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within male gonad development IMP
IMP: Inferred from mutant phenotype
22863743 MGI
acts upstream of or within male meiotic nuclear division IMP
IMP: Inferred from mutant phenotype
22863743 MGI
acts upstream of or within miRNA metabolic process IMP
IMP: Inferred from mutant phenotype
22863743 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
22863743 MGI
acts upstream of or within regulation of cell morphogenesis IMP
IMP: Inferred from mutant phenotype
22863743 MGI
acts upstream of or within synaptonemal complex assembly IMP
IMP: Inferred from mutant phenotype
22863743 MGI
Cellular Component GO Annotation Evidence References Source
located in P-body IDA
IDA: Inferred from direct assay
19898466 MGI
part of RISC complex IDA
IDA: Inferred from direct assay
19536157 MGI
located in nucleus IDA
IDA: Inferred from direct assay
22863743 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein argonaute-4

  • Piwi/Argonaute family protein meIF2C4

  • argonaute 4

  • argonaute RISC catalytic component 4

  • eukaryotic translation initiation factor 2C, 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00455 AGO4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ago4 NCBI NCBI:192670