Bicd2 - BICD cargo adaptor 2 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 76895

Summary

Enables several functions, including dynactin binding activity; dynein complex binding activity; and dynein light intermediate chain binding activity. Involved in several processes, including microtubule anchoring at microtubule organizing center; minus-end-directed organelle transport along microtubule; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Acts upstream of or within microtubule-based movement. Located in Golgi apparatus and cytoplasmic vesicle. Is expressed in several structures, including central nervous system; dorsal root ganglion; olfactory epithelium; and retina. Human ortholog(s) of this gene implicated in spinal muscular atrophy with lower extremity predominance 2A and spinal muscular atrophy with lower extremity predominante 2B. Orthologous to human BICD2 (BICD cargo adaptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Bicd2 Products (3)

mRNA	Protein	Name
NM_001039179.2	NP_001034268.1	protein bicaudal D homolog 2 isoform 1
NM_001039180.2	NP_001034269.1	protein bicaudal D homolog 2 isoform 3
NM_029791.4	NP_084067.1	protein bicaudal D homolog 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables dynactin binding	IDA IDA: Inferred from direct assay	22956769	MGI
enables dynein complex binding	IDA IDA: Inferred from direct assay	22956769	MGI
enables dynein light intermediate chain binding	IPI IPI: Inferred from physical interaction	25272277	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11483508	MGI
enables small GTPase binding	IPI IPI: Inferred from physical interaction	12447383	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in microtubule anchoring at microtubule organizing center	IMP IMP: Inferred from mutant phenotype	19825938	MGI
acts upstream of or within microtubule-based movement	IDA IDA: Inferred from direct assay	11483508	MGI
involved in minus-end-directed organelle transport along microtubule	IMP IMP: Inferred from mutant phenotype	12447383	MGI
involved in protein localization to Golgi apparatus	IMP IMP: Inferred from mutant phenotype	25962623	MGI
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	25962623	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11483508	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12447383	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein bicaudal D homolog 2	bic-D 2 bicaudal D homolog 2

Bicd2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Bicd2	Q921C5	Rab6a	Mus musculus	P35279	Pull Down	20360680
Intra	Bicd2	Q921C5	Rab6a	Mus musculus	P35279	Y2H	20360680

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01499	BICD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bicd2	NCBI	NCBI:23299