2. Gene
  3. Slc9a8 - solute carrier family 9 (sodium/hydrogen exchanger), member 8 Gene

Slc9a8 - solute carrier family 9 (sodium/hydrogen exchanger), member 8 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as NHE8; NHE-8; 1200006P13Rik; 6430709P13Rik

Gene ID: 77031 | Gene type: protein coding

About Slc9a8

Summary

This gene encodes a member of the Na+/H+ exchanger (NHE) family of integral membrane transporter proteins. The encoded protein is expressed on the apical membrane of the intestinal epithelial cells and plays an important role in mucosal protection. Loss of the encoded protein in mice results in a decrease in the number of goblet and mucin-positive cells, disorganization of the Mucin layer, and a decrease in mucosal pH in the colon. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Slc9a8 Products(3)

mRNA Protein Name
NM_001304540.1 NP_001291469.1 sodium/hydrogen exchanger 8 isoform c
NM_001304542.1 NP_001291471.1 sodium/hydrogen exchanger 8 isoform d
NM_148929.3 NP_683731.1 sodium/hydrogen exchanger 8 isoform a
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in acrosome assembly IMP
IMP: Inferred from mutant phenotype
28476888 MGI
involved in regulation of intracellular pH IDA
IDA: Inferred from direct assay
29958869 MGI
Cellular Component GO Annotation Evidence Reference Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
28476888 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
23220221 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sodium/hydrogen exchanger 8

Na(+)/H(+) exchanger 8

sodium/proton exchanger NHE8

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13347 SLC9A8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc9a8 NCBI NCBI:23315