Creb3l4 - cAMP responsive element binding protein 3-like 4 Gene

Also Known as JAL; CREB4; acre1; AIBZIP; TISP40; 1700012K17Rik; 5330432F22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 78284

Summary

This gene encodes a CREB (cyclic AMP-responsive element-binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein may play a role in adiposity and male germ cell development. Homozygous knockout mice for this gene show increased adipogenesis, elevated testicular germ cell Apoptosis and defects in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Creb3l4 Products (3)

mRNA Protein Name
NM_001307934.1 NP_001294863.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1
NM_001307935.1 NP_001294864.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2
NM_030080.3 NP_084356.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
11956138 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15938716 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
15938716 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15938716 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15938716 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
15938716 MGI
acts upstream of or within spermatogenesis IMP
IMP: Inferred from mutant phenotype
16107712 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclic AMP-responsive element-binding protein 3-like protein 4

  • androgen-induced basic leucine zipper

  • attaching to CRE-like 1

  • cAMP-responsive element-binding protein 3-like protein 4

  • transcript induced in spermiogenesis protein 40

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03153 CREB3L4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Creb3l4 NCBI NCBI:148327