CREB3L4 - cAMP responsive element binding protein 3 like 4 Gene

Also Known as JAL; hJAL; ATCE1; CREB3; CREB4; AIBZIP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 148327

About CREB3L4

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,967,487-153,974,359 (from NCBI)

This gene has 13 transcripts (splice variants), 195 orthologues and 9 paralogues. Broad expression in prostate (RPKM 52.3), stomach (RPKM 10.0) and 20 other tissues.

Summary

This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

CREB3L4 Products (5)

mRNA Protein Name
NM_001255978.2 NP_001242907.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1
NM_001255979.2 NP_001242908.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1
NM_001255980.2 NP_001242909.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2
NM_001255981.2 NP_001242910.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2
NM_130898.4 NP_570968.1 cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16236796 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
16236796 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
16236796 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CREB3L4 Protein Structure

bZIP_1

bZIP_1: bZIP transcription factor (215 - 273)

  • 0
  • 100
  • 200
  • 300
  • 395 a.a.
Protein Preferred Names Protein Names

cyclic AMP-responsive element-binding protein 3-like protein 4

  • CREB-4

Related Diseases

Diseases Alias
Nemaline Myopathy 1

  • Cap Myopathy 1

  • NEM1

  • Nemaline Myopathy 1, Autosomal Dominant Or Recessive

  • Nemaline Myopathy, Type 1

  • CAPM1

  • Cap Disease

  • Cap Myopathy Tpm3-Related

  • Nemaline Myopathy 1 Autosomal Dominant Or Recessive

  • Myopathy, Nemaline, Type 1

  • Cap Myopathy
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Myxofibrosarcoma

  • Fibromyxosarcoma

  • Fibromyxoid Sarcoma

  • Myxoid Malignant Fibrous Histiocytoma

  • Dermatofibrosarcoma Protuberans, Myxoid
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03153 CREB3L4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CREB3L4 RGD RGD:1359278
Canis familiaris CREB3L4 VGNC VGNC:39599
Macaca mulatta CREB3L4 VGNC VGNC:71437
Mus musculus CREB3L4 MGD MGI:1916603
Felis catus CREB3L4 VGNC VGNC:61169
Bos taurus CREB3L4 VGNC VGNC:27697
Others CREB3L4 NCBI