MMP28 - matrix metallopeptidase 28 Gene

Also Known as MM28; MMP25; MMP-25; MMP-28; EPILYSIN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79148

About MMP28

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,756,249-35,795,641 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 206 orthologues and 23 paralogues. Broad expression in fat (RPKM 8.8), skin (RPKM 8.6) and 18 other tissues.

Summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

MMP28 Products (3)

mRNA Protein Name
NM_001032278.3 NP_001027449.1 matrix metalloproteinase-28 isoform 3 precursor
NM_024302.5 NP_077278.1 matrix metalloproteinase-28 isoform 1 preproprotein
NM_032950.4 NP_116568.1 matrix metalloproteinase-28 isoform 2 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21152186 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MMP28 Protein Structure

PG_binding_1

PG_binding_1: Putative peptidoglycan binding domain (33 - 86)

  • 0
  • 100
  • 130 a.a.
Protein Preferred Names Protein Names

matrix metalloproteinase-28

  • matrix metalloprotease MMP25

MMP28 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MMP28 Q9H239 FURIN Homo sapiens P09958
Confocal
21152186
Intra
MMP28 Q9H239 FURIN Homo sapiens P09958
Anti Tag CoIP
21152186
Intra
MMP28 Q9H239 FURIN Homo sapiens P09958
Anti Bait CoIP
21152186
Intra
MMP28 Q9H239 TRIM68 Homo sapiens Q6AZZ1
Anti Tag CoIP
33961781
Intra
MMP28 Q9H239 TRIM68 Homo sapiens Q6AZZ1
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08547 MMP28 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MMP28 VGNC VGNC:43287
Macaca mulatta MMP28 VGNC VGNC:74755
Rattus norvegicus MMP28 RGD RGD:1311573
Mus musculus MMP28 MGD MGI:2153062
Bos taurus MMP28 VGNC VGNC:31528
Felis catus MMP28 VGNC VGNC:63539
Others MMP28 NCBI