2. Gene
  3. Lrat - lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) Gene

Lrat - lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 1300010A18Rik

Gene ID: 79235 | Gene type: protein coding

About Lrat

Summary

Enables phosphatidylcholine-retinol O-acyltransferase activity. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of lipid transport; and retinoid metabolic process. Located in endoplasmic reticulum. Is expressed in several structures, including extraembryonic component; gut; liver; midbrain; and reproductive system. Used to study Leber congenital amaurosis 14. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 14 and retinitis pigmentosa. Orthologous to human LRAT (lecithin retinol Acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Lrat Products(1)

mRNA Protein Name
NM_023624.4 NP_076113.1 lecithin retinol acyltransferase
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables O-acyltransferase activity IDA
IDA: Inferred from direct assay
11108736 MGI
enables phosphatidylcholine-retinol O-acyltransferase activity IMP
IMP: Inferred from mutant phenotype
28758396 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within embryo development IGI
IGI: Inferred from genetic interaction
18093970 MGI
acts upstream of or within positive regulation of lipid transport IGI
IGI: Inferred from genetic interaction
23105095 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
acts upstream of or within retinol metabolic process IGI
IGI: Inferred from genetic interaction
18093970 MGI
acts upstream of or within retinol metabolic process IMP
IMP: Inferred from mutant phenotype
18093970 MGI
involved in retinol metabolic process IMP
IMP: Inferred from mutant phenotype
28758396 MGI
acts upstream of or within vitamin A metabolic process IDA
IDA: Inferred from direct assay
11108736 MGI
involved in vitamin A metabolic process IMP
IMP: Inferred from mutant phenotype
28758396 MGI
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
28758396 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

lecithin retinol acyltransferase

phosphatidylcholine--retinol O-acyltransferase

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07776 LRAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-169085 LRAT-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrat NCBI NCBI:9227