Htr3a - 5-hydroxytryptamine receptor 3A Gene

Also Known as 5HT3; Htr3; 5-HT3; 5-HT3A

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 79246

About Htr3a

Primary_assembly 8: 49,242,020-49,254,389 reverse strand.mRatBN7.2:CM026981.1

This gene has 3 transcripts (splice variants), 215 orthologues, 41 paralogues and is associated with 6 phenotypes. Biased expression in Brain (RPKM 17.), Testes (RPKM 1.3) and 1 other tissue.

Summary

Enables serotonin-gated cation-selective channel activity. Involved in several processes, including positive regulation of ion transmembrane transporter activity; response to cocaine; and response to ethanol. Located in several cellular components, including axon; neuronal cell body; and plasma membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in irritable bowel syndrome. Orthologous to human HTR3A (5-hydroxytryptamine receptor 3A). [provided by Alliance of Genome Resources, Apr 2022]

Htr3a Products (1)

mRNA Protein Name
NM_024394.3 NP_077370.2 5-hydroxytryptamine receptor 3A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables serotonin-gated monoatomic cation channel activity IDA
IDA: Inferred from direct assay
12196560 RGD
Biological Process GO Annotation Evidence References Source
involved in behavioral response to ethanol IEP
IEP: Inferred from expression pattern
25722691 RGD
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
10854267 RGD
involved in positive regulation of ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
10854267 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
17105936 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
16876304 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
17650111 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
11876772 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17650111 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
11876772 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
11876772 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Htr3a Protein Structure

LIC

LIC: TIGR00860 (4 - 481)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
Protein Preferred Names Protein Names

5-hydroxytryptamine receptor 3A

  • 5-HT-3

  • 5-HT3 receptor

  • 5-HT3-A

  • 5-HT3R

  • 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic

  • 5-hydroxytryptamine receptor 3

  • serotonin receptor 3A

  • serotonin-gated ion channel receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06470 HTR3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06471 Htr3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06472 Htr3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Htr3a NCBI NCBI:3359