HTR3A - 5-hydroxytryptamine receptor 3A Gene

Homo sapiens

Also known as HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R

Gene ID: 3359 | Gene type: protein coding

About HTR3A

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:113,975,108-113,990,313 (from NCBI)

This gene has 7 transcripts (splice variants), 215 orthologues and 45 paralogues. Biased expression in lymph node (RPKM 3.0), appendix (RPKM 1.1) and 6 other tissues.

Summary

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

HTR3A Products(4)

mRNA	Protein	Name
NM_000869.6	NP_000860.3	5-hydroxytryptamine receptor 3A isoform b precursor
NR_046363.2
NM_001161772.3	NP_001155244.1	5-hydroxytryptamine receptor 3A isoform c
NM_213621.4	NP_998786.3	5-hydroxytryptamine receptor 3A isoform a precursor

HTR3A Protein Structure

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
478 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 3A

5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	5-hydroxytryptamine receptor 3
5HT3 serotonin receptor	serotonin receptor 3A
serotonin-gated ion channel receptor

Related Diseases

Diseases

Alias

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Psychotic Disorder

Psychotic Disorders	Mental Or Behavioural Disorder
Psychotic	Mental Disorders

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Trichothiodystrophy 7, Nonphotosensitive

TTD7	Nonphotosensitive Trichothiodystrophy 7
Trichothiodystrophy 7, Non-Photosensitive

Amnestic Disorder

Amnesia	Amnestic Syndrome
Korsakoff'S Psychosis Or Syndrome	Amnesic Syndrome
Amnestic Disorder In Conditions Classified Elsewhere	Korsakoff Psychosis Or Syndrome, Nonalcoholic
Nonalcoholic Organic Amnesic Syndrome	Organic Amnesic Syndrome

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Ischemic Colitis

Colitis, Ischemic

Irreversible Ischaemic Colitis

Motion Sickness

Airsickness	Carsickness
Seasickness	Travel Sickness
Riders' Vertigo

Gastroparesis

Gastroparesis Syndrome	Delayed Gastric Emptying
Gastric Atonia	Gastroparalysis

Stuttering

Stammering	Familial Persistent Stuttering
Stuttering, Familial Persistent 1

Sudden Infant Death Syndrome

SIDS	Sudden Infant Death Syndrome, Susceptibility To
Cot Death	Crib Death
Sudden Death Of Nonspecific Cause In Infancy	Sudden Infant Death
Death, Sudden, Syndrome, Infant

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Serotonin Syndrome

Serotonergic Syndrome	Serotonin Storm
Serotonin Toxicity	Serotonin Toxidrome
Malignant Carcinoid Syndrome

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Neuroleptic Malignant Syndrome

Machado-Joseph Disease

SCA3	MJD
Spinocerebellar Ataxia 3	Azorean Disease
Spinocerebellar Ataxia Type 3	Azorean Neurologic Disease
Spinopontine Atrophy	Nigrospinodentatal Degeneration
Spinocerebellar Atrophy	Spinocerebellar Atrophy Iii
Spinocerebellar Atrophy Type 3	Azorean Ataxia
Azorean Disease Of The Nervous System	Machado Disease
Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia	Disease, Machado-Joseph
Ataxia, Spinocerebellar

Hyperekplexia

Hereditary Hyperekplexia	Kok Disease
Congenital Stiff Man Syndrome	Familial Startle Disease
Sthe	Stiff-Baby Syndrome
Hereditary Hyperexplexia	Startle Disease
Exaggerated Startle Reaction	Hyperexplexia Hereditary
Startle Disease, Familial	Startle Reaction, Exaggerated
Stiff-Man Syndrome, Congenital	Stiff-Person Syndrome, Congenital
Congenital Stiff-Man Syndrome	Congenital Stiff-Person Syndrome
Familial Hyperekplexia	Startle Syndrome
Stiff Baby Syndrome	Hyperekplexia, Hereditary
Stiff-Person Syndrome

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Social Phobia

Phobia, Social	Phobia Social
Phobic Anxiety Disorder

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Fibromyalgia

Diffuse Myofascial Pain Syndrome	Fibromyalgia Syndrome
Fibromyalgia-Fibromyositis Syndrome	Fibromyositis
Fibrositis	Fms
Myofascial Pain Syndrome	Myofascial Pain Syndromes

Constipation

Sialadenitis

Sialoadenitis	Adenitis, Salivary Gland
Salivary Gland Inflammation	Salivary Gland Adenitis
Sialitis	Inflammation Of Salivary Gland
Inflammation Of Salivary Duct Or Gland	Salivary Glandular Adenitis
Sialoangiitis	Sialoangitis
Sialodochitis

Irritable Bowel Syndrome

Irritable Colon	Psychogenic Ibs
Ibs - [Irritable Bowel Syndrome]	Spastic Bowel Syndrome

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Headache

Headache Disorder

Brunner Syndrome

Monoamine Oxidase A Deficiency	Antisocial Behavior
BRNRS	Deficiency Of Monoamine Oxidase A
X-Linked Monoamine Oxidase Deficiency	Susceptibility To Antisocial Behavior
Antisocial Behavior, Susceptibility To	Anti-Social Behavior

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

Personality Disorder

Personality Disorders	Character Disorder
Personality	Specific Personality Disorders
Enduring Personality Change After Psychiatric Illness

Pedophilia

Paedophilia

Borderline Personality Disorder

Obsessive-Compulsive Disorder

OCD	Obsessive-Compulsive Disorder, Susceptibility To
Anancastic Neurosis	Obsessive Compulsive Disorder
Anankastic Neurosis	Obsessive-Compulsive Neurosis
Obsessive Compulsive Behavior

Generalized Anxiety Disorder

Anxiety Generalized

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against	Alcohol Dependence, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Cocaine Abuse

Cocaine-Related Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS06470	HTR3A Human Pre-designed siRNA Set A	/	Unkown
HY-RS06471	Htr3a Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS06472	Htr3a Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HTR3A	MGD	MGI:96282
Felis catus	HTR3A	VGNC	VGNC:67673
Bos taurus	HTR3A	VGNC	VGNC:29998
Macaca mulatta	HTR3A	VGNC	VGNC:73542
Canis familiaris	HTR3A	VGNC	VGNC:41829
Rattus norvegicus	HTR3A	RGD	RGD:61818