HTR3A - 5-hydroxytryptamine receptor 3A Gene

Also Known as HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3359

About HTR3A

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:113,975,108-113,990,313 (from NCBI)

This gene has 7 transcripts (splice variants), 215 orthologues and 45 paralogues. Biased expression in lymph node (RPKM 3.0), appendix (RPKM 1.1) and 6 other tissues.

Summary

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

HTR3A Products (4)

mRNA	Protein	Name
NM_000869.6	NP_000860.3	5-hydroxytryptamine receptor 3A isoform b precursor
NR_046363.2
NM_001161772.3	NP_001155244.1	5-hydroxytryptamine receptor 3A isoform c
NM_213621.4	NP_998786.3	5-hydroxytryptamine receptor 3A isoform a precursor

HTR3A Protein Structure

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
478 a.a.

Protein Preferred Names	Protein Names
5-hydroxytryptamine receptor 3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 5-hydroxytryptamine receptor 3 5HT3 serotonin receptor serotonin receptor 3A serotonin-gated ion channel receptor

HTR3A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HTR3A	P46098	HTR3E	Homo sapiens	A5X5Y0-3	Anti Bait CoIP	17392525
Intra	HTR3A	P46098	HTR3E	Homo sapiens	A5X5Y0-3	Confocal	17392525
Intra	HTR3A	P46098	HTR3E	Homo sapiens	A5X5Y0-3	Saturation Binding	17392525
Intra	HTR3A	P46098	HTR3E	Homo sapiens	A5X5Y0-1	Pull Down	17392525
Intra	HTR3A	P46098	HTR3E	Homo sapiens	A5X5Y0-1	Saturation Binding	17392525
Intra	HTR3A	P46098	HTR3E	Homo sapiens	A5X5Y0-1	Anti Bait CoIP	17392525
Intra	HTR3A	P46098	HTR3E	Homo sapiens	A5X5Y0-1	Confocal	17392525
Intra	HTR3A	P46098	HTR3D	Homo sapiens	Q70Z44	Saturation Binding	17392525
Intra	HTR3A	P46098	HTR3D	Homo sapiens	Q70Z44	Confocal	17392525
Intra	HTR3A	P46098	HTR3D	Homo sapiens	Q70Z44	Anti Bait CoIP	17392525
Intra	HTR3A	P46098	HTR3D	Homo sapiens	Q70Z44	Pull Down	17392525
Intra	HTR3A	P46098	HTR3C	Homo sapiens	Q8WXA8	Pull Down	17392525
Intra	HTR3A	P46098	HTR3C	Homo sapiens	Q8WXA8	Confocal	17392525
Intra	HTR3A	P46098	HTR3C	Homo sapiens	Q8WXA8	Anti Bait CoIP	17392525
Intra	HTR3A	P46098	HTR3C	Homo sapiens	Q8WXA8	Saturation Binding	17392525

Cross: Cross-species interaction Intra: Intraspecies interaction

HTR3A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84340	HTR3A Antibody (YA4037)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P84340A	HTR3A Antibody (YA4037)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Mood Disorder	Mood Disorders Episodic Mood Disorder
Trichothiodystrophy 7, Nonphotosensitive	TTD7 Nonphotosensitive Trichothiodystrophy 7 Trichothiodystrophy 7, Non-Photosensitive
Amnestic Disorder	Amnesia Amnestic Syndrome Korsakoff'S Psychosis Or Syndrome Amnesic Syndrome Amnestic Disorder In Conditions Classified Elsewhere Korsakoff Psychosis Or Syndrome, Nonalcoholic Nonalcoholic Organic Amnesic Syndrome Organic Amnesic Syndrome
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Ischemic Colitis	Colitis, Ischemic Irreversible Ischaemic Colitis
Motion Sickness	Airsickness Carsickness Seasickness Travel Sickness Riders' Vertigo
Gastroparesis	Gastroparesis Syndrome Delayed Gastric Emptying Gastric Atonia Gastroparalysis
Stuttering	Stammering Familial Persistent Stuttering Stuttering, Familial Persistent 1
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Eating Disorder	Eating Disorders Feeding And Eating Disorders
Serotonin Syndrome	Serotonergic Syndrome Serotonin Storm Serotonin Toxicity Serotonin Toxidrome Malignant Carcinoid Syndrome
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1
Neuroleptic Malignant Syndrome
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Hyperekplexia	Hereditary Hyperekplexia Kok Disease Congenital Stiff Man Syndrome Familial Startle Disease Sthe Stiff-Baby Syndrome Hereditary Hyperexplexia Startle Disease Exaggerated Startle Reaction Hyperexplexia Hereditary Startle Disease, Familial Startle Reaction, Exaggerated Stiff-Man Syndrome, Congenital Stiff-Person Syndrome, Congenital Congenital Stiff-Man Syndrome Congenital Stiff-Person Syndrome Familial Hyperekplexia Startle Syndrome Stiff Baby Syndrome Hyperekplexia, Hereditary Stiff-Person Syndrome
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Social Phobia	Phobia, Social Phobia Social Phobic Anxiety Disorder
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Fibromyalgia	Diffuse Myofascial Pain Syndrome Fibromyalgia Syndrome Fibromyalgia-Fibromyositis Syndrome Fibromyositis Fibrositis Fms Myofascial Pain Syndrome Myofascial Pain Syndromes
Constipation
Sialadenitis	Sialoadenitis Adenitis, Salivary Gland Salivary Gland Inflammation Salivary Gland Adenitis Sialitis Inflammation Of Salivary Gland Inflammation Of Salivary Duct Or Gland Salivary Glandular Adenitis Sialoangiitis Sialoangitis Sialodochitis
Irritable Bowel Syndrome	Irritable Colon Psychogenic Ibs Ibs - [Irritable Bowel Syndrome] Spastic Bowel Syndrome
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Headache	Headache Disorder
Brunner Syndrome	Monoamine Oxidase A Deficiency Antisocial Behavior BRNRS Deficiency Of Monoamine Oxidase A X-Linked Monoamine Oxidase Deficiency Susceptibility To Antisocial Behavior Antisocial Behavior, Susceptibility To Anti-Social Behavior
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Personality Disorder	Personality Disorders Character Disorder Personality Specific Personality Disorders Enduring Personality Change After Psychiatric Illness
Pedophilia	Paedophilia
Borderline Personality Disorder
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Generalized Anxiety Disorder	Anxiety Generalized
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcohol Dependence, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Cocaine Abuse	Cocaine-Related Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06470	HTR3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06471	Htr3a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06472	Htr3a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HTR3A	MGD	MGI:96282
Felis catus	HTR3A	VGNC	VGNC:67673
Bos taurus	HTR3A	VGNC	VGNC:29998
Macaca mulatta	HTR3A	VGNC	VGNC:73542
Canis familiaris	HTR3A	VGNC	VGNC:41829
Rattus norvegicus	HTR3A	RGD	RGD:61818
Others	HTR3A	NCBI