HTR3A Antibody (YA4037)(PBS only)
(Synonyms: HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R)HTR3A Antibody (YA4037) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HTR3A.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:100-1:500 | 1:200-1:400 | 1:10000 |
Product Details
HTR3A Antibody (YA4037) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HTR3A.
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Host Mouse
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 55 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 55 kDa
Purified recombinant fragment of human HTR3A (AA: extra 24-157) expressed in E. Coli.
affinity purified.
Non-conjugated
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HTR3A forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons
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Subcellular Localization
Postsynaptic cell membrane; Multi-pass membrane protein; Cell membrane; Multi-pass membrane protein
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Expression
Tissue_specificity:Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta -
Isoforms & Post-Translational Modification
P46098 has 5 isomers: P46098-1: 55280 Da (predicted); P46098-2: 58388 Da (predicted); P46098-3: 53763 Da (predicted); P46098-4: 55894 Da (predicted); P46098-5: 59002 Da (predicted).
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Subunit
Forms homopentameric as well as heteropentameric serotonin-activated cation-selective channel complexes with HTR3B or HTR3C or HTR3D or HTR3E. The homomeric complex is functional but exhibits low conductance with modified voltage dependence, and decreased agonist and antagonist affinity. Heteropentameric complexes display properties which resemble that of neuronal serotonin-activated channels in vivo (PubMed:10521471, PubMed:15809299, PubMed:17392525, PubMed:9950429). Interacts with RIC3 (PubMed:15809299)
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SwissProt ID
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Synonyms
HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R
Documentation
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