SETD6 - SET domain containing 6, protein lysine methyltransferase Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79918

About SETD6

Cytogenetic location: 16q21 Genomic coordinates (GRCh38): 16:58,515,479-58,523,842 (from NCBI)

This gene has 13 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 13.6), skin (RPKM 9.3) and 25 other tissues.

Summary

This gene encodes a methyltransferase that adds a methyl group to the histone H2AZ, which is involved in nuclear receptor-dependent transcription. The protein also interacts with several endogenous proteins which are involved in nuclear hormone receptor signaling. A related pseudogene is located on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

SETD6 Products (2)

mRNA Protein Name
NM_001160305.4 NP_001153777.1 N-lysine methyltransferase SETD6 isoform a
NM_024860.3 NP_079136.2 N-lysine methyltransferase SETD6 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
21131967 GOA
enables S-adenosyl-L-methionine binding IDA
IDA: Inferred from direct assay
21515635 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21131967 GOA
enables protein-lysine N-methyltransferase activity IDA
IDA: Inferred from direct assay
21131967 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
21131967 GOA
involved in peptidyl-lysine monomethylation IDA
IDA: Inferred from direct assay
21131967 GOA
involved in regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
21131967 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
21131967 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SETD6 Protein Structure

SET

SET: SET domain (74 - 286)

Rubis-subs-bind

Rubis-subs-bind: Rubisco LSMT substrate-binding (334 - 465)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
Protein Preferred Names Protein Names

N-lysine methyltransferase SETD6

  • SET domain-containing protein 6

SETD6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
SETD6 Q8TBK2 Rela Mus musculus Q04207
Methyltransferase Ass
21131967
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 30

  • Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12rb1 Deficiency

  • IMD30

  • Il12rb1 Deficiency

  • Mendelian Susceptibility To Interleukin 12 Receptor Beta 1 Deficiency

  • Msmd Due To Complete Il12rb1 Deficiency

  • Msmd Due To Complete Interleukin 12 Receptor Beta 1 Deficiency

  • Il-12râ1 Deficiency

  • Mendelian Susceptibility To Mycobacterial Infections Due To Il12 Deficiency

  • Immunodeficiency, Type 30
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12746 SETD6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21697 Prex1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SETD6 MGD MGI:1913333
Macaca mulatta SETD6 VGNC VGNC:77313
Felis catus SETD6 VGNC VGNC:65045
Canis familiaris SETD6 VGNC VGNC:46057
Rattus norvegicus SETD6 RGD RGD:1560538
Bos taurus SETD6 VGNC VGNC:34496
Others SETD6 NCBI