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GLRA3 - glycine receptor alpha 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8001

About GLRA3

Cytogenetic location: 4q34.1 Genomic coordinates (GRCh38): 4:174,636,920-174,829,247 (from NCBI)

This gene has 4 transcripts (splice variants), 201 orthologues and 45 paralogues. Biased expression in brain (RPKM 2.6), adrenal (RPKM 0.4) and 1 other tissue.

Summary

This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]

GLRA3 Products (2)

mRNA	Protein	Name
NM_001042543.3	NP_001036008.1	glycine receptor subunit alpha-3 isoform b precursor
NM_006529.4	NP_006520.2	glycine receptor subunit alpha-3 isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables extracellularly glycine-gated chloride channel activity	IDA IDA: Inferred from direct assay	26416729	GOA
enables glycine-gated chloride ion channel activity	IDA IDA: Inferred from direct assay	9677400	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chloride transmembrane transport	IDA IDA: Inferred from direct assay	9677400	GOA
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	26416729	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of glycine-gated chloride channel complex	IDA IDA: Inferred from direct assay	9677400	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	26416729	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	9677400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLRA3 Protein Structure

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
464 a.a.

Protein Preferred Names	Protein Names
glycine receptor subunit alpha-3	glycine receptor, alpha-3 polypeptide

GLRA3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GLRA3	O75311	KCTD2	Homo sapiens	Q14681	Anti Tag CoIP	33961781
Intra	GLRA3	O75311	KCTD2	Homo sapiens	Q14681	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hyperekplexia	Hereditary Hyperekplexia Kok Disease Congenital Stiff Man Syndrome Familial Startle Disease Sthe Stiff-Baby Syndrome Hereditary Hyperexplexia Startle Disease Exaggerated Startle Reaction Hyperexplexia Hereditary Startle Disease, Familial Startle Reaction, Exaggerated Stiff-Man Syndrome, Congenital Stiff-Person Syndrome, Congenital Congenital Stiff-Man Syndrome Congenital Stiff-Person Syndrome Familial Hyperekplexia Startle Syndrome Stiff Baby Syndrome Hyperekplexia, Hereditary Stiff-Person Syndrome
Brain Stem Infarction	Brain Stem Infarctions Brainstem Infarction
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05494	GLRA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GLRA3	RGD	RGD:621229
Canis familiaris	GLRA3	VGNC	VGNC:41270
Mus musculus	GLRA3	MGD	MGI:95749
Felis catus	GLRA3	VGNC	VGNC:62590
Macaca mulatta	GLRA3	VGNC	VGNC:73076
Bos taurus	GLRA3	VGNC	VGNC:56969
Others	GLRA3	NCBI