Apobec3 - apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 Gene

Also Known as Arp3; Rfv3; Cem15; Apobec; Gm20117

Species: Mus musculus

Gene Type: protein coding
Gene ID: 80287

Summary

Predicted to enable several functions, including hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; identical protein binding activity; and zinc ion binding activity. Involved in negative regulation of transposition and negative regulation of viral genome replication. Acts upstream of or within hematopoietic progenitor cell differentiation; regulation of defense response to virus; and regulation of viral life cycle. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and sensory organ. Orthologous to several human genes including APOBEC3F (Apolipoprotein B mRNA editing enzyme catalytic subunit 3F). [provided by Alliance of Genome Resources, Apr 2022]

Apobec3 Products (3)

mRNA Protein Name
NM_001160415.1 NP_001153887.1 DNA dC->dU-editing enzyme APOBEC-3 isoform 1
NM_001347041.1 NP_001333970.1 DNA dC->dU-editing enzyme APOBEC-3 isoform 3
NM_030255.3 NP_084531.2 DNA dC->dU-editing enzyme APOBEC-3 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18509452 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within hematopoietic progenitor cell differentiation IGI
IGI: Inferred from genetic interaction
24029230 MGI
involved in negative regulation of viral genome replication IDA
IDA: Inferred from direct assay
16378963 MGI
acts upstream of or within regulation of defense response to virus IMP
IMP: Inferred from mutant phenotype
293683 MGI
acts upstream of or within regulation of viral life cycle IMP
IMP: Inferred from mutant phenotype
293683 MGI
involved in retrotransposon silencing IDA
IDA: Inferred from direct assay
16527742 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16527742 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA dC->dU-editing enzyme APOBEC-3

  • apolipoprotein B editing complex 3

  • apolipoprotein B mRNA-editing complex 3

  • recovery from Friend virus 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W279260 APOBEC3G-IN-1 Inhibitor 96.88% Unkown
HY-148138 Deaminase inhibitor-1 Inhibitor 99.62% Unkown
HY-122156 IMB-301 Inhibitor 99.08% Unkown
HY-148042 HIV-1 inhibitor-47 Inhibitor 98.0% Unkown
HY-E70584 Recombinant APOBEC3A (A3A) Protein / Unkown
HY-RS00836 APOBEC3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00837 APOBEC3C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00838 APOBEC3D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00839 APOBEC3F Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00840 APOBEC3G Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00841 APOBEC3H Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120157 Vif-ElonginC interaction inhibitor 1 Inhibitor / Unkown
HY-124870 N.41 Inhibitor / Unkown
HY-183925 Redoxal Inhibitor / Unkown
HY-RS16406 APOBEC3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown