Hnrnpl - heterogeneous nuclear ribonucleoprotein L Gene

Rattus norvegicus

Also known as Hnrpl; hnrnp-L

Gene ID: 80846 | Gene type: protein coding

About Hnrnpl

Summary

Enables mRNA 3'-UTR binding activity and mRNA CDS binding activity. Involved in several processes, including cellular response to amino acid starvation; positive regulation of mRNA binding activity; and regulation of gene expression. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and systemic scleroderma. Orthologous to human HNRNPL (heterogeneous nuclear ribonucleoprotein L). [provided by Alliance of Genome Resources, Apr 2022]

Hnrnpl Products(2)

mRNA	Protein	Name
NM_001134760.1	NP_001128232.1	heterogeneous nuclear ribonucleoprotein L isoform a
NM_032619.2	NP_116008.2	heterogeneous nuclear ribonucleoprotein L isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	15798208	RGD
enables mRNA CDS binding	IDA IDA: Inferred from direct assay	16980303	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18161049	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amino acid starvation	IDA IDA: Inferred from direct assay	19273590	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	15798208	RGD
involved in negative regulation of mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	22570490	RGD
involved in positive regulation of translation	IMP IMP: Inferred from mutant phenotype	19273590	RGD
involved in response to peptide	IEP IEP: Inferred from expression pattern	12576095	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18161049	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

heterogeneous nuclear ribonucleoprotein L

heterogenous nuclear ribonucleoprotein L

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06274	HNRNPL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hnrnpl	NCBI	NCBI:3191

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