Cubn - cubilin Gene

Also Known as IFCR; MGA1; GP280

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 80848

Summary

Enables several functions, including cargo receptor activity; Hemoglobin binding activity; and identical protein binding activity. Involved in several processes, including cobalamin catabolic process; cobalamin transport; and endocytic Hemoglobin import into cell. Located in several cellular components, including brush border membrane; clathrin-coated pit; and cytoplasmic vesicle. Part of receptor complex. Orthologous to human CUBN (cubilin). [provided by Alliance of Genome Resources, Apr 2022]

Cubn Products (1)

mRNA	Protein	Name
NM_053332.4	NP_445784.3	cubilin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cargo receptor activity	IMP IMP: Inferred from mutant phenotype	14576052	RGD
enables hemoglobin binding	IDA IDA: Inferred from direct assay	11805171	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	11595644	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12724130	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cobalamin catabolic process	IMP IMP: Inferred from mutant phenotype	14576052	RGD
involved in cobalamin transport	IMP IMP: Inferred from mutant phenotype	14576052	RGD
involved in endocytic hemoglobin import into cell	IMP IMP: Inferred from mutant phenotype	11805171	RGD
involved in in utero embryonic development	IDA IDA: Inferred from direct assay	15616221	RGD
involved in receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	11595644	RGD
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	14576052	RGD
involved in response to nutrient	IMP IMP: Inferred from mutant phenotype	15616221	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi-associated vesicle	IDA IDA: Inferred from direct assay	14576052	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	19202329	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	12724130	RGD
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	14576052	RGD
located in coated vesicle	IDA IDA: Inferred from direct assay	14576052	RGD
located in endocytic vesicle membrane	IDA IDA: Inferred from direct assay	15578272	RGD
located in lysosomal lumen	IDA IDA: Inferred from direct assay	15578272	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17990981	RGD
part of receptor complex	IDA IDA: Inferred from direct assay	19202329	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cubilin	460 kDa receptor glycoprotein 280 intrinsic factor-cobalamin receptor intrinsic factor-vitamin B12 receptor

Cubn Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Cubn	O70244	Cubn	Rattus norvegicus	O70244	Crosslink	20237569
Intra	Cubn	O70244	Cubn	Rattus norvegicus	O70244	GMS	20237569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03356	CUBN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cubn	NCBI	NCBI:8029