2. Gene
  3. Kcnip2 - Kv channel-interacting protein 2 Gene

Kcnip2 - Kv channel-interacting protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as KChIP2

Gene ID: 80906 | Gene type: protein coding

About Kcnip2

Summary

This gene encodes a member of the voltage-gated potassium channel-interacting protein (KCNIP) family. KCNIP family members are small calcium binding proteins that commonly exhibit unique variation at their N-termini, and which modulate A-type potassium channels. This gene is predominantly expressed in the adult heart, and to a lesser extent in the brain. Disruption of this gene is associated with susceptibility to cardiac arrhythmias and lack of transient outward potassium current in ventricular myocytes, and downregulated expression is associated with cardiac hypertrophy. The encoded protein has also been implicated as a repressor of immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Kcnip2 Products(4)

mRNA Protein Name
NM_001276358.1 NP_001263287.1 Kv channel-interacting protein 2 isoform d
NM_030716.3 NP_109641.2 Kv channel-interacting protein 2 isoform b
NM_145703.2 NP_663749.1 Kv channel-interacting protein 2 isoform a
NM_145704.2 NP_663750.1 Kv channel-interacting protein 2 isoform c
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables potassium channel regulator activity IMP
IMP: Inferred from mutant phenotype
20943905 MGI
Biological Process GO Annotation Evidence Reference Source
involved in regulation of potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
20943905 MGI
Cellular Component GO Annotation Evidence Reference Source
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
19713751 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Kv channel-interacting protein 2

A-type potassium channel modulatory protein 2

potassium channel-interacting protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07133 KCNIP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnip2 NCBI NCBI:30819